Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | CFB | P00751 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 6/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.43 |
| ▸ | FADS1 | O60427 | 4/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.40 |
| ▸ | HTR3B | O95264 | 1/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.40 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1852745 | 0.79 | CFB (0.49) | CFBTAAR1HTR3A | |
| SCHEMBL9558516 | 0.75 | TAAR1 (0.45) | HPGDKMT2ACFBTAAR1MEN1 | |
| Clidafidine SCHEMBL11607487 | 0.75 | CFB (0.60) | KMT2ACFBTAAR1MEN1LMNA | |
| SCHEMBL29920861 | 0.72 | ADRA2A (0.59) | KMT2AMEN1NPC1RAB9ALMNA | |
| SCHEMBL1686631 | 0.72 | FADS1 (0.59) | KMT2AEGFRFADS1MEN1NPC1 | |
| SCHEMBL29385329 | 0.72 | CFB (0.53) | HPGDKMT2ACFBTAAR1MEN1 | |
| SCHEMBL5786191 | 0.71 | CFB (0.43) | KMT2ACFBNPC1RAB9AMAPT | |
| SCHEMBL2798318 | 0.70 | ADRA2A (0.49) | HPGDKMT2ACFBEGFRLCK | |
| SCHEMBL9558789 | 0.70 | CFB (0.48) | HPGDCFBTAAR1GAAMAPT | |
| SCHEMBL7629026 | 0.70 | ADRA2A (0.50) | CFBTAAR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090156581-A1 | Aminergic pharmaceutical compositions and methods | BOARD OF TRUSTREES OF MICHIGAN STATE UNIVERSITY (US) | 2009-06-18 | — | — | US | disclosed |
| EP-1874356-A2 | AMINERGIC PHARMACEUTICAL COMPOSITIONS AND METHODS | Board of Trustees of Michigan State University (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006113485-A2 | AMINERGIC PHARMACEUTICAL COMPOSITIONS AND METHODS | BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY (US) | 2006-10-26 | — | — | WO | disclosed |