Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 15/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 13/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 13/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 7/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | GMNN | O75496 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | CFB | P00751 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3608336 | 0.78 | — | — | |
| SCHEMBL3608335 | 0.78 | — | — | |
| SCHEMBL19538200 | 0.78 | — | — | |
| SCHEMBL1852745 | 0.78 | CFB (0.49) | ADRA2AADRA2BADRA2CADRA1ACYP3A4 | |
| SCHEMBL4401199 | 0.76 | ADRA2A (0.45) | ADRA2AADRA2BADRA2CADRA1ACYP3A4 | |
| SCHEMBL11440748 | 0.73 | TAAR1 (0.75) | ADRA2AADRA2BADRA2CADRA1ACYP3A4 | |
| Clidafidine SCHEMBL11607487 | 0.73 | CFB (0.60) | ADRA2AADRA2BADRA2CADRA1ACYP3A4 | |
| SCHEMBL24533674 | 0.72 | — | — | |
| SCHEMBL13620321 | 0.72 | — | — | |
| SCHEMBL19533129 | 0.72 | ADRA2A (0.42) | ADRA2AADRA2BADRA2CADRA1ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6451727-B2 | PREPARED FROM CHIRAL AMINO ALCOHOLS; SUITABLE FOR ASSYMETRIC CATALYSIS; FOR TRANSFER HYDROGENATION OF KETONES AND IMINES; ENANTIOMORPHS; PURITY; EFFICIENCY | THE PENN STATE RESEARCH FOUNDATION | 2002-09-17 | — | — | US | claimed |
| US-20010044546-A1 | Prepared from chiral amino alcohols; suitable for assymetric catalysis; for transfer hydrogenation of ketones and imines; enantiomorphs; purity; efficiency | THE PENN STATE RESEARCH FOUNDATION | 2001-11-22 | — | — | US | claimed |
| US-6255493-B1 | REACTING IMIDATE ESTER WITH CHIRAL ALCOHOL IN PRESENCE OF TRANSITION METAL CATALYST TO FORM BIS(4-(R)-PHENYLOXAZOLIN-2-YL-METHYL)AMINE LIGANDS; USE TO MAKE RUTHENIUM CATALYST FOR TRANSFER HYDROGENATION | THE PENN STATE RESEARCH FOUNDATION | 2001-07-03 | — | — | US | claimed |
| EP-1030849-A1 | TRANSITION METAL-CATALYZED REACTIONS BASED ON CHIRAL AMINE OXAZOLINYL LIGANDS | The Pennsylvania State University (US) | 2000-08-30 | — | — | EP | claimed |
| WO-1999024410-A1 | TRANSITION METAL-CATALYZED REACTIONS BASED ON CHIRAL AMINE OXAZOLINYL LIGANDS | THE PENN STATE RESEARCH FOUNDATION (US) | 1999-05-20 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010044546-A1 | Prepared from chiral amino alcohols; suitable for assymetric catalysis; for transfer hydrogenation of ketones and imines; enantiomorphs; purity; efficiency | AADAT, ADH1C, ADH5 | ADRA2A 855/4885ADRA2B 1271/4885ADRA2C 911/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.