SCHEMBL18529756

SCHEMBL18529756

CC(C)(C)c1ccc([C@H]2C[C@@H]2C(N)=O)cn1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 2/20 0.44
CHRNA7 P36544 2/20 0.43
CYP3A4 P08684 2/20 0.40
NAMPT P43490 2/20 0.40
FAAH O00519 3/20 0.40
ALDH1A1 P00352 1/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2C9 P11712 1/20 0.40
CYP2C19 P33261 1/20 0.40
KDM1A O60341 2/20 0.36
NPC1 O15118 1/20 0.36
MAPT P10636 1/20 0.36
RAB9A P51151 1/20 0.36
AURKA O14965 1/20 0.36
LCK P06239 1/20 0.36
FYN P06241 1/20 0.36
IGF1R P08069 1/20 0.36
MET P08581 1/20 0.36
KIT P10721 1/20 0.36
FGFR2 P21802 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1476708 0.87 FFAR1 (0.49) HRH3CHRNA7CYP3A4NAMPTALDH1A1
SCHEMBL27699501 0.85 HRH3 (0.58) HRH3CHRNA7CYP3A4NAMPTFAAH
SCHEMBL1473448 0.80 HRH3 (0.40) HRH3CHRNA7CYP3A4NAMPTALDH1A1
Formic Acid SCHEMBL27699508 0.78 CHRNA7 (0.41) HRH3CHRNA7CYP3A4NAMPTKDM1A
SCHEMBL18923908 0.77 FAAH (0.40) HRH3CYP3A4NAMPTFAAHALDH1A1
SCHEMBL12999402 0.76 HTT (0.51) CYP3A4FAAHALDH1A1CYP1A2CYP2C9
SCHEMBL18541381 0.74 BCL2 (0.41) CYP3A4NAMPTFAAHKDM1A
SCHEMBL18898575 0.74 ALDH1A1 (0.67) CYP3A4FAAHALDH1A1CYP1A2CYP2C9
SCHEMBL18611059 0.74 ALDH1A1 (0.67) CYP3A4FAAHALDH1A1CYP1A2CYP2C9
SCHEMBL23550031 0.73 HRH3 (0.58) HRH3CHRNA7CYP3A4NAMPTKDM1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2017031204-A1 CYCLOPROPYLDERIVATIVES AND THEIR USE AS KINASE INHIBITORS Karyopharm Therapeutics Inc. (US) 2017-02-23 WO disclosed