Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 6/20 | 0.34 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
| ▸ | RXRG | P48443 | 1/20 | 0.32 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.32 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25211649 | 0.75 | HDAC6 (0.45) | HDAC6P4HTMFFAR1KEAP1ALOX15 | |
| SCHEMBL16028301 | 0.75 | HDAC6 (0.45) | HDAC6P4HTMSYKSMN1; SMN2ADRB2 | |
| SCHEMBL18571382 | 0.72 | HDAC6 (0.42) | HDAC6P4HTMFFAR1RXRARXRB | |
| SCHEMBL16561852 | 0.72 | GRM8 (0.42) | — | |
| SCHEMBL16644964 | 0.69 | HDAC6 (0.37) | HDAC6P4HTMFFAR1CYP2C8CYP2C9 | |
| SCHEMBL17933366 | 0.68 | FDPS (0.35) | — | |
| SCHEMBL29599886 | 0.66 | HDAC6 (0.37) | HDAC6P4HTMFFAR1SYKRXRA | |
| SCHEMBL11593277 | 0.66 | SMN1; SMN2 (0.45) | HDAC6ALOX15HTTSMN1; SMN2ADRB2 | |
| SCHEMBL18534217 | 0.64 | RXRA (0.50) | P4HTMFFAR1RXRARXRBRXRG | |
| SCHEMBL992041 | 0.63 | FDPS (0.44) | HDAC6P4HTMFFAR1KEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2976346-B1 | PHOSPHOHISTIDINE AND PHOSPHOTYROSINE ANALOGUES | UNIV SHEFFIELD (GB) | 2017-02-22 | — | — | EP | disclosed |