Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 2/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | GRK6 | P43250 | 1/20 | 0.30 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14737356 | 0.89 | ABCB11 (0.33) | — | |
| SCHEMBL28111553 | 0.75 | LMNA (0.37) | — | |
| SCHEMBL14751396 | 0.72 | ABCB11 (0.30) | — | |
| SCHEMBL14737765 | 0.70 | ABCB11 (0.30) | — | |
| SCHEMBL20598293 | 0.70 | PDE10A (0.33) | — | |
| SCHEMBL14744566 | 0.70 | — | — | |
| SCHEMBL21678405 | 0.68 | DGAT1 (0.41) | — | |
| SCHEMBL31070127 | 0.68 | DGAT1 (0.41) | — | |
| SCHEMBL1370138 | 0.68 | DGAT1 (0.38) | — | |
| SCHEMBL18535271 | 0.66 | ABL1 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763990-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2017-02-22 | — | — | EP | disclosed |