Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX12 | P18054 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18535193 | 0.81 | HTT (0.47) | ALOX12LMNAMAPK1ALDH1A1KDM4E | |
| SCHEMBL7498201 | 0.81 | LMNA (0.49) | ALOX12LMNAMAPK1BRD4ALDH1A1 | |
| SCHEMBL25121378 | 0.80 | LMNA (0.45) | ALOX12LMNAMAPK1BRD4ALDH1A1 | |
| SCHEMBL14566671 | 0.80 | LMNA (0.45) | ALOX12LMNAMAPK1BRD4ALDH1A1 | |
| SCHEMBL5199567 | 0.79 | LMNA (0.48) | ALOX12LMNAMAPK1BRD4ALDH1A1 | |
| SCHEMBL22726442 | 0.79 | ALOX12 (0.48) | ALOX12LMNAMAPK1BRD4ALDH1A1 | |
| SCHEMBL19015565 | 0.77 | LMNA (0.39) | ALOX12LMNAMAPK1BRD4ALDH1A1 | |
| SCHEMBL18844475 | 0.74 | BRD4 (0.53) | ALOX12LMNAMAPK1BRD4EHMT2 | |
| SCHEMBL10288823 | 0.74 | PTPN1 (0.46) | ALOX12LMNAMAPK1BRD4ALDH1A1 | |
| SCHEMBL19997193 | 0.74 | PTPN1 (0.46) | ALOX12LMNAMAPK1BRD4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2083819-B1 | PDE10 INHIBITORS AND RELATED COMPOSITIONS AND METHODS | OMEROS CORP (US) | 2017-02-22 | — | — | EP | disclosed |