Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.40 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18535188 | 0.81 | ALOX12 (0.55) | LMNAALOX12MAPK1MEN1KMT2A | |
| SCHEMBL5199567 | 0.81 | LMNA (0.48) | LMNAALOX12MAPK1MEN1KMT2A | |
| SCHEMBL22726442 | 0.77 | ALOX12 (0.48) | LMNAALOX12MAPK1MEN1KMT2A | |
| SCHEMBL18203599 | 0.72 | EHMT2 (0.48) | LMNAALOX12MAPK1MEN1KMT2A | |
| SCHEMBL2956324 | 0.71 | MEN1 (0.39) | LMNAMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL19019547 | 0.68 | ESR1 (0.41) | LMNAMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL18844475 | 0.67 | BRD4 (0.53) | LMNAALOX12MAPK1EHMT2BRD4 | |
| SCHEMBL28626811 | 0.67 | EHMT2 (0.40) | LMNAALOX12MAPK1MEN1KMT2A | |
| SCHEMBL29778116 | 0.66 | HDAC2 (0.49) | LMNAALOX12MAPK1EHMT2EPHX2 | |
| SCHEMBL31039937 | 0.66 | POLB (0.49) | MEN1KMT2AALDH1A1HTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1077967-B1 | BIPHENYL OXO-ACETIC ACIDS USEFUL IN THE TREATMENT OF INSULIN RESISTANCE AND HYPERGLYCEMIA | WYETH CORP (US) | 2002-12-04 | — | — | EP | disclosed |
| US-6391897-B2 | (4'-BENZOFURAN-3-YL-BIPHENYL-4-YLOXY)-ACETIC ACID, FOR EXAMPLE; INHIBIT PROTEIN-TYROSINE PHOSPHATASES (PTPASES) | AMERICAN HOME PRODUCTS CORPORATION | 2002-05-21 | — | — | US | disclosed |
| US-6369072-B2 | Biphenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia | AMERICAN HOME PRODUCTS CORPORATION | 2002-04-09 | — | — | US | disclosed |
| US-20010053785-A1 | Biphenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia | WYETH | 2001-12-20 | — | — | US | disclosed |
| US-20010041715-A1 | Biphenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia | AMERICAN HOME PRODUCTS | 2001-11-15 | — | — | US | disclosed |
| US-6232322-B1 | SUCH AS (4'-BENZOFURAN-3-YL-BIPHENYL-4-YLOXY)-ACETIC ACID OR SALT | AMERICAN HOME PRODUCTS CORPORATION | 2001-05-15 | — | — | US | disclosed |
| EP-1077967-A2 | BIPHENYL OXO-ACETIC ACIDS USEFUL IN THE TREATMENT OF INSULIN RESISTANCE AND HYPERGLYCEMIA | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-02-28 | — | — | EP | disclosed |
| WO-1999058518-A2 | BIPHENYL OXO-ACETIC ACIDS USEFUL IN THE TREATMENT OF INSULIN RESISTANCE AND HYPERGLYCEMIA | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-11-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010053785-A1 | Biphenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia | GPR119, INSR, IAPP | LMNA 1435/4885ALOX12 1418/4885MAPK1 2116/4885 |
| US-20010041715-A1 | Biphenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia | GPR119, INSR, IAPP | LMNA 1435/4885ALOX12 1418/4885MAPK1 2116/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.