Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 3/20 | 0.61 |
| ▸ | AGXT | P21549 | 2/20 | 0.61 |
| ▸ | APP | P05067 | 5/20 | 0.59 |
| ▸ | MAOB | P27338 | 1/20 | 0.57 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA7 | P43166 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20000873 | 0.83 | APP (0.80) | IDO1AGXTAPPMAOBNPC1 | |
| SCHEMBL27455063 | 0.80 | IDO1 (0.67) | IDO1AGXTAPPMAOBCA12 | |
| SCHEMBL31270 | 0.80 | IDO1 (0.67) | IDO1AGXTAPPMAOBCA12 | |
| SCHEMBL34413 | 0.80 | IDO1 (0.67) | IDO1AGXTAPPMAOBCA12 | |
| SCHEMBL9618281 | 0.79 | APP (0.67) | APPMAOBNPC1POLBRAB9A | |
| SCHEMBL5505882 | 0.79 | APP (0.67) | IDO1AGXTAPPMAOBNPC1 | |
| SCHEMBL28784521 | 0.79 | APP (0.67) | IDO1AGXTAPPMAOBNPC1 | |
| Methoxymethane SCHEMBL28823290 | 0.78 | IDO1 (0.64) | IDO1AGXTAPPMAOBCA12 | |
| Hydrochloric Acid SCHEMBL28912134 | 0.78 | IDO1 (0.68) | IDO1AGXTAPPMAOBCA12 | |
| Bromide SCHEMBL28558295 | 0.78 | IDO1 (0.64) | IDO1AGXTAPPMAOBCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10494388-B2 | Compounds useful in the synthesis of halichondrin B analogs | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2019-12-03 | — | — | US | disclosed |
| US-20180162885-A1 | COMPOUNDS USEFUL IN THE SYNTHESIS OF HALICHONDRIN B ANALOGS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2018-06-14 | — | — | US | disclosed |
| US-9856276-B2 | Compounds useful in the synthesis of halichondrin B analogs | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2018-01-02 | — | — | US | disclosed |
| US-20160376294-A1 | COMPOUNDS USEFUL IN THE SYNTHESIS OF HALICHONDRIN B ANALOGS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2016-12-29 | — | — | US | disclosed |
| US-9382262-B2 | Compounds useful in the synthesis of halichondrin B analogs | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2016-07-05 | — | — | US | disclosed |
| US-20150175620-A1 | COMPOUNDS USEFUL IN THE SYNTHESIS OF HALICHONDRIN B ANALOGS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-06-25 | — | — | US | disclosed |
| US-8927597-B2 | Compounds useful in the synthesis of halichondrin B analogs | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2015-01-06 | — | — | US | disclosed |
| EP-2528914-B1 | FURO[3,2-B]PYRANE DERIVATIVES USEFUL IN THE SYNTHESIS OF HALICHONDRIN B ANALOGS | EISAI R&D MAN CO LTD (JP) | 2014-06-11 | — | — | EP | disclosed |
| US-20130123519-A1 | COMPOUNDS USEFUL IN THE SYNTHESIS OF HALICHONDRIN B ANALOGS | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-05-16 | — | — | US | disclosed |
| US-8350067-B2 | Compounds useful in the synthesis of halichondrin B analogs | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2013-01-08 | — | — | US | disclosed |
| WO-2009005672-A1 | ANTIDIABETIC AZAINDOLES AND DIAZAINDOLES | MERCK & CO., INC. (US) | 2009-01-08 | — | — | WO | disclosed |
| US-7183417-B2 | Simple stereocontrolled synthesis of salinosporamide A | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2007-02-27 | — | — | US | disclosed |
| EP-1745048-A2 | SIMPLE STEREOCONTROLLED SYNTHESIS OF SALINOSPORAMIDE A | The President and Fellows of Harvard College (US) | 2007-01-24 | — | — | EP | disclosed |
| WO-2005113558-A2 | SIMPLE STEREOCONTROLLED SYNTHESIS OF SALINOSPORAMIDE A | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2005-12-01 | — | — | WO | disclosed |
| US-20050228186-A1 | Simple stereocontrolled synthesis of salinosporamide A | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2005-10-13 | — | — | US | disclosed |
| US-5371239-A | Pyrrole nitrile or nitropyrrole compounds | AMERICAN CYANAMID COMPANY (US) | 1994-12-06 | — | — | US | disclosed |
| EP-0039157-A1 | Chlorination of 4-methoxybenzoyl chloride | ELI LILLY AND COMPANY (US) | 1981-11-04 | — | — | EP | disclosed |
| US-4119721-A | HYPOTENSIVE AGENTS, ADRENERGIC BLOCKING AGENTS | MERCK & CO., INC. (US) | 1978-10-10 | — | — | US | disclosed |
| US-4119630-A | VASODILATORS, BETA-ADRENERGIC BLOCKING AGENTS | MERCK & CO., INC. (US) | 1978-10-10 | — | — | US | disclosed |
| US-4053605-A | VASODILATORS, HYPOTENSIVES, BETA-ADRENERGIC BLOCKING AGENTS | MERCK & CO., INC. (US) | 1977-10-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180162885-A1 | COMPOUNDS USEFUL IN THE SYNTHESIS OF HALICHONDRIN B ANALOGS | ERLIN1, ERLIN2, MAN1B1 | IDO1 4806/4885AGXT 1563/4885APP 4595/4885 |
| US-10494388-B2 | Compounds useful in the synthesis of halichondrin B analogs | ERLIN1, ERLIN2, MAN1B1 | IDO1 4806/4885AGXT 1563/4885APP 4595/4885 |
| US-20150175620-A1 | COMPOUNDS USEFUL IN THE SYNTHESIS OF HALICHONDRIN B ANALOGS | ERLIN1, ERLIN2, MAN1B1 | IDO1 4806/4885AGXT 1563/4885APP 4595/4885 |
| US-20050228186-A1 | Simple stereocontrolled synthesis of salinosporamide A | CYP51A1, ERG28, STS | IDO1 3581/4885AGXT 1945/4885APP 4549/4885 |
| US-20160376294-A1 | COMPOUNDS USEFUL IN THE SYNTHESIS OF HALICHONDRIN B ANALOGS | ERLIN1, ERLIN2, MAN1B1 | IDO1 4806/4885AGXT 1563/4885APP 4595/4885 |
| US-20130123519-A1 | COMPOUNDS USEFUL IN THE SYNTHESIS OF HALICHONDRIN B ANALOGS | ERLIN1, ERLIN2, MAN1B1 | IDO1 4806/4885AGXT 1563/4885APP 4595/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.