Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 5/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.36 |
| ▸ | HTR7 | P34969 | 3/20 | 0.36 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.35 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.35 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.35 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22794388 | 0.86 | GNAI3 (0.41) | GNAI3GNAO1GNAI1HTT | |
| SCHEMBL25831695 | 0.84 | GNAO1 (0.43) | GNAI3GNAO1GNAI1THRBHTT | |
| SCHEMBL23602775 | 0.83 | PRMT6 (0.35) | HRH1KDM1AHTR7GNAI3GNAO1 | |
| SCHEMBL2621574 | 0.83 | KDM1A (0.46) | CYP2D6KDM1AHTR7PABPC1NPC1 | |
| SCHEMBL21107910 | 0.82 | PRMT6 (0.35) | HRH1KDM1AHTR7GNAI3GNAO1 | |
| SCHEMBL23806558 | 0.82 | GNAI3 (0.33) | KDM1AHTR7GNAI3GNAO1GNAI1 | |
| SCHEMBL23696344 | 0.82 | PRMT6 (0.35) | HRH1KDM1AHTR7GNAI3GNAO1 | |
| SCHEMBL21107904 | 0.81 | KDM4E (0.33) | KDM1AHTR7GNAI3GNAO1GNAI1 | |
| SCHEMBL24060967 | 0.81 | KDM1A (0.51) | KDM1AHTR7NPC1HTR1A | |
| SCHEMBL23806789 | 0.81 | HTT (0.33) | HRH1KDM1AHTR7GNAI3GNAO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3298022-B1 | NOVEL ANNELATED PHENOXYACETAMIDES | BOEHRINGER INGELHEIM INT (DE) | 2019-06-05 | — | — | EP | disclosed |
| US-10221202-B2 | Annelated phenoxyacetamides | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2019-03-05 | — | — | US | disclosed |
| US-20170313732-A1 | NOVEL ANNELATED PHENOXYACETAMIDES | BOEHRINGER INGELHEIM INT (DE) | 2017-11-02 | — | — | US | disclosed |
| US-20170313732-A1 | NOVEL ANNELATED PHENOXYACETAMIDES | BOEHRINGER INGELHEIM INT (DE) | 2017-11-02 | — | — | US | disclosed |
| US-20170050992-A1 | NOVEL ANNELATED PHENOXYACETAMIDES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-02-23 | — | — | US | disclosed |
| US-20170050992-A1 | NOVEL ANNELATED PHENOXYACETAMIDES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170313732-A1 | NOVEL ANNELATED PHENOXYACETAMIDES | EP300, NAT1, AADAC | CYP2D6 69/4885CYP2C19 143/4885HRH1 148/4885 |
| US-10221202-B2 | Annelated phenoxyacetamides | EP300, NAT1, REN | CYP2D6 93/4885CYP2C19 104/4885HRH1 398/4885 |
| US-20170050992-A1 | NOVEL ANNELATED PHENOXYACETAMIDES | EP300, NAT1, AADAC | CYP2D6 118/4885CYP2C19 213/4885HRH1 211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.