Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.39 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ACP3 | P15309 | 1/20 | 0.37 |
| ▸ | CTSA | P10619 | 4/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.35 |
| ▸ | GLS | O94925 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL363392 | 0.82 | NR3C2 (0.47) | ALDH1A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL29048166 | 0.80 | ALDH1A1 (0.45) | ALDH1A1MEN1KMT2ANPSR1NR3C2 | |
| SCHEMBL11088063 | 0.80 | ALDH1A1 (0.45) | ALDH1A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL14108456 | 0.80 | ALDH1A1 (0.45) | ALDH1A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL29998155 | 0.79 | ALDH1A1 (0.42) | ALDH1A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL185647 | 0.77 | TAAR1 (0.57) | ALDH1A1LMNANPSR1TAAR1CYP2C19 | |
| SCHEMBL185424 | 0.76 | ALDH1A1 (0.42) | ALDH1A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL18181442 | 0.76 | TAAR1 (0.55) | ESR1TAAR1CYP1A2CYP3A4 | |
| SCHEMBL185645 | 0.73 | ALDH1A1 (0.40) | ALDH1A1MEN1KMT2ALMNAMAPT | |
| SCHEMBL3668722 | 0.73 | ALDH1A1 (0.45) | ALDH1A1KMT2AMAPTNR3C2PTGER3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401260-A1 | DIOXO-IMIDAZOLIDINE DERIVATIVES, WHICH INHIBIT THE ENZYME SOAT-1, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | Galderma Research & Development (FR) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097465-A1 | DIOXO-IMIDAZOLIDINE DERIVATIVES, WHICH INHIBIT THE ENZYME SOAT-1, AND PHARMACEUTICAL AND COSMETIC COMPOSITIONS CONTAINING THEM | GALDERMA RESEARCH & DEVELOPMENT (FR) | 2010-09-02 | — | — | WO | disclosed |