SCHEMBL18541925

SCHEMBL18541925

Cc1c(OC#N)cccc1OC#N

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.39
MAPK1 P28482 2/20 0.39
TDP1 Q9NUW8 1/20 0.39
L3MBTL1 Q9Y468 1/20 0.39
CA12 O43570 1/20 0.32
CA1 P00915 1/20 0.32
CA2 P00918 1/20 0.32
CA4 P22748 1/20 0.32
CA7 P43166 1/20 0.32
CA9 Q16790 1/20 0.32
CA14 Q9ULX7 1/20 0.32
TSHR P16473 2/20 0.31
CYP3A4 P08684 2/20 0.31
PIK3CA P42336 1/20 0.31
HTR1B P28222 1/20 0.31
POLB P06746 1/20 0.31
GAA P10253 1/20 0.31
KDM4E B2RXH2 2/20 0.30
ALDH1A1 P00352 2/20 0.30
AR P10275 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18469427 0.91 CA1 (0.42) MAPTMAPK1TDP1CA12CA1
SCHEMBL29489121 0.89 MAPT (0.46) MAPTL3MBTL1TSHRCYP3A4HTR1B
SCHEMBL9854216 0.89 MAPT (0.46) MAPTL3MBTL1TSHRCYP3A4HTR1B
SCHEMBL18469428 0.86 L3MBTL1 (0.43) MAPTMAPK1TDP1L3MBTL1HTR1B
SCHEMBL18427386 0.85 LMNA (0.36) ALDH1A1LMNA
SCHEMBL22172091 0.85 TSHR (0.43) MAPK1TSHRPOLBGAAALDH1A1
SCHEMBL8848846 0.85 ALDH1A1 (0.42) MAPTPOLBGAAKDM4EALDH1A1
SCHEMBL18427384 0.84 KDM4E (0.34) MAPTMAPK1TDP1L3MBTL1TSHR
SCHEMBL14529048 0.84 MAPT (0.42) MAPTMAPK1TDP1L3MBTL1HTR1B
SCHEMBL31084408 0.84 ALDH1A1 (0.31) KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3580258-B1 OLIGOMERIC POLYOL COMPOSITIONS PRESIDIUM USA INC (US) 2021-08-11 EP disclosed
EP-3609940-B1 POLYMER SUITABLE AS A THICKENER BYK CHEMIE GMBH (DE) 2021-06-30 EP disclosed
US-10270075-B2 Separator having adhesive layer, manufacturing method of the same, and electrochemical device having the same E I DU PONT DE NEMOURS AND COMPANY (US) 2019-04-23 US disclosed
EP-3320574-B1 SEPARATOR HAVING ADHESIVE LAYER, MANUFACTURING METHOD OF THE SAME, AND ELECTROCHEMICAL DEVICE HAVING THE SAME DU PONT (US) 2019-04-03 EP disclosed
US-9735410-B2 Composite separator for electrochemical cell capable of sustained shutdown E I DU PONT DE NEMOURS AND COMPANY (US) 2017-08-15 US disclosed
US-9702218-B2 Use of elastomers to produce gels for treating a wellbore M-1 Drilling Fluids U.K. Ltd. (GB) 2017-07-11 US disclosed
US-20170050990-A1 METHODS AND COMPOSITIONS FOR PREPARING SILICA AEROGELS AEROGEL TECHNOLOGIES, LLC (US) 2017-02-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170050990-A1 METHODS AND COMPOSITIONS FOR PREPARING SILICA AEROGELS STOM, RAD54L, MTCL3 MAPT 3402/4885MAPK1 4778/4885TDP1 3023/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.