Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.46 |
| ▸ | HCAR3 | P49019 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | ACACB | O00763 | 4/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL185452 | 0.77 | HCAR3 (0.64) | HDAC3HDAC1HDAC2HDAC6HCAR3 | |
| SCHEMBL16047037 | 0.75 | HCAR3 (0.62) | HDAC3HDAC1HDAC2HDAC6HCAR3 | |
| SCHEMBL186008 | 0.74 | GRM5 (0.39) | HDAC3HDAC1HDAC2HDAC6HCAR3 | |
| SCHEMBL20924284 | 0.72 | HDAC1 (0.54) | HDAC3HDAC1HDAC2HDAC6HCAR3 | |
| SCHEMBL27756056 | 0.72 | CDK1 (0.43) | HDAC3HDAC1HDAC2HDAC6MAPK1 | |
| SCHEMBL10589105 | 0.71 | CYP1A2 (0.41) | MAPK1KDM4EGAA | |
| SCHEMBL14667236 | 0.71 | HDAC1 (0.57) | HDAC3HDAC1HDAC2HDAC6HCAR3 | |
| SCHEMBL31056972 | 0.71 | EGFR (0.49) | MAPK1MAPK8MAPK9 | |
| SCHEMBL186360 | 0.70 | VNN1 (0.40) | HCAR3MAPK1ACACBGAA | |
| SCHEMBL200701 | 0.70 | HDAC3 (0.41) | HDAC3HDAC1HDAC2HDAC6HCAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |