Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 5/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.41 |
| ▸ | VNN1 | O95497 | 3/20 | 0.41 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.40 |
| ▸ | ACACB | O00763 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16824372 | 0.81 | TRPM8 (0.37) | HDAC3HDAC1HDAC2HDAC6VNN1 | |
| SCHEMBL186008 | 0.79 | GRM5 (0.39) | HDAC3HDAC1HDAC2HDAC6VNN1 | |
| SCHEMBL16824381 | 0.79 | HCAR3 (0.39) | HDAC3HDAC1HDAC2HDAC6VNN1 | |
| SCHEMBL10589105 | 0.76 | CYP1A2 (0.41) | MAPK1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL198068 | 0.76 | CCNE1 (0.35) | HCAR3ALDH1A1 | |
| SCHEMBL200700 | 0.76 | HCAR3 (0.61) | HDAC3HDAC1HDAC2HDAC6VNN1 | |
| SCHEMBL186360 | 0.75 | VNN1 (0.40) | VNN1HCAR3ACACBMAPK1PKM | |
| SCHEMBL26548778 | 0.75 | KCNH3 (0.47) | VNN1ACACBMAPK1ALDH1A1MEN1 | |
| SCHEMBL8681274 | 0.73 | MAPK1 (0.49) | HDAC3HDAC1HDAC2HDAC6VNN1 | |
| SCHEMBL185620 | 0.72 | LMNA (0.35) | ALDH1A1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |