Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALPL | P05186 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | PGR | P06401 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23846530 | 0.82 | TSHR (0.50) | TSHRALDH1A1MAPK1GLASMN1; SMN2 | |
| SCHEMBL7535289 | 0.81 | ALDH1A1 (0.54) | TSHRALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL15053746 | 0.81 | TSHR (0.69) | TSHRALDH1A1MAPK1GLASMN1; SMN2 | |
| SCHEMBL18546037 | 0.80 | PGR (0.51) | TSHRALDH1A1MAPK1SMN1; SMN2MAPT | |
| SCHEMBL31525238 | 0.78 | TSHR (0.67) | TSHRALDH1A1MAPK1GLASMN1; SMN2 | |
| SCHEMBL23833704 | 0.78 | TSHR (0.49) | TSHRALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL15052896 | 0.78 | TSHR (0.66) | TSHRALDH1A1MAPK1GLASMN1; SMN2 | |
| SCHEMBL15480593 | 0.77 | ALDH1A1 (0.53) | TSHRALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL18545993 | 0.77 | ALDH1A1 (0.58) | TSHRALDH1A1MAPK1SMN1; SMN2MAPT | |
| SCHEMBL15212006 | 0.75 | ALPL (0.63) | TSHRALDH1A1MAPK1SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017030987-A9 | COMPOSITIONS AND METHODS FOR TREATING MULTIPLE MYELOMA | THE BROAD INSTITUTE, INC. (US) | 2018-07-12 | — | — | WO | disclosed |
| WO-2017030987-A1 | COMPOSITIONS AND METHODS FOR TREATING MULTIPLE MYELOMA | THE BROAD INSTITUTE, INC. (US) | 2017-02-23 | — | — | WO | disclosed |