Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.51 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 3/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6534758 | 0.82 | KDM4E (0.69) | ALDH1A1TSHRTP53RAB9APGR | |
| SCHEMBL18545995 | 0.81 | TSHR (0.58) | ALDH1A1TSHRPGRL3MBTL1MAPT | |
| SCHEMBL15480593 | 0.80 | ALDH1A1 (0.53) | ALDH1A1TSHRLMNATP53RAB9A | |
| SCHEMBL18546037 | 0.80 | PGR (0.51) | ALDH1A1TSHRLMNAPGRL3MBTL1 | |
| SCHEMBL8602441 | 0.79 | L3MBTL1 (0.60) | ALDH1A1TSHRLMNATP53L3MBTL1 | |
| SCHEMBL6534675 | 0.78 | PGR (0.71) | ALDH1A1TP53NR2F2RAB9APGR | |
| SCHEMBL15953603 | 0.77 | SIRT2 (0.60) | LMNANR2F2RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL15212140 | 0.74 | ALPL (0.62) | LMNAPGRMAPTSMN1; SMN2 | |
| SCHEMBL7529463 | 0.73 | TP53 (0.80) | ALDH1A1LMNATP53L3MBTL1KMT2A | |
| SCHEMBL407215 | 0.72 | L3MBTL1 (0.64) | ALDH1A1LMNATP53L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20020183393-A1 | Inhibitors of Rho C | ICONIX PHARMACEUTICALS INC. | 2002-12-05 | — | — | US | disclosed |
| WO-2002022565-A1 | INHIBITORS OF RHO C | ICONIX PHARMACEUTICALS, INC. (US) | 2002-03-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020183393-A1 | Inhibitors of Rho C | RHOC, ROCK1, RHOA | ALDH1A1 3776/4885TSHR 488/4885LMNA 2037/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.