Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | ACACB | O00763 | 4/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ACACA | Q13085 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | MITF | O75030 | 2/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1853478 | 0.83 | DRD1 (0.46) | KMT2AALDH1A1SMN1; SMN2NPSR1MEN1 | |
| SCHEMBL4171846 | 0.82 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL13278546 | 0.78 | NQO1 (0.47) | ACACBPARP10CNR2 | |
| SCHEMBL2553737 | 0.76 | ALDH1A1 (0.40) | KMT2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL15775340 | 0.73 | PARP10 (0.43) | ALDH1A3KMT2AACACBPARP10ALDH1A1 | |
| SCHEMBL7512548 | 0.73 | ALDH1A3 (0.55) | ALDH1A3KMT2AACACBPARP10ALDH1A1 | |
| SCHEMBL4441582 | 0.72 | AKR1C3 (0.49) | — | |
| SCHEMBL2550741 | 0.72 | LMNA (0.46) | KMT2AALDH1A1SMN1; SMN2NPSR1 | |
| SCHEMBL2542920 | 0.72 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2 | |
| SCHEMBL5311123 | 0.72 | ESR1 (0.34) | KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323988-A1 | ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITORS | Wyeth LLC (US) | 2011-05-25 | — | — | EP | disclosed |
| WO-2010009290-A1 | ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITORS | WYETH (US) | 2010-01-21 | — | — | WO | disclosed |