Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 10/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 10/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20233648 | 0.88 | CHRM2 (0.51) | MTNR1AMTNR1BCHRM2CHRM1CHRM3 | |
| SCHEMBL20322409 | 0.88 | CHRM2 (0.51) | MTNR1AMTNR1BCHRM2CHRM1CHRM3 | |
| SCHEMBL30230412 | 0.88 | CHRM2 (0.51) | MTNR1AMTNR1BCHRM2CHRM1CHRM3 | |
| SCHEMBL30230087 | 0.88 | CHRM2 (0.51) | MTNR1AMTNR1BCHRM2CHRM1CHRM3 | |
| SCHEMBL21341911 | 0.85 | MTNR1A (0.46) | MTNR1AMTNR1BACHE | |
| SCHEMBL20443287 | 0.84 | MTNR1A (0.44) | MTNR1AMTNR1BCHRM2CHRM1CHRM3 | |
| SCHEMBL12881236 | 0.82 | ALOX5 (0.49) | CHRM2CHRM1CHRM3ALOX5ACHE | |
| SCHEMBL22047298 | 0.81 | TAAR1 (0.49) | MTNR1AMTNR1BALOX5CYP2D6ACHE | |
| SCHEMBL5245979 | 0.79 | ALOX5 (0.47) | MTNR1AMTNR1BALOX5CYP2D6ACHE | |
| SCHEMBL14463255 | 0.77 | ALOX5 (0.45) | CHRM2CHRM1CHRM3ALOX5ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017030814-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF BROMODOMAIN-CONTAINING PROTEINS | Arvinas, Inc. (US) | 2017-02-23 | — | — | WO | disclosed |