SCHEMBL18552198

SCHEMBL18552198

c1ccc(-c2ccc3[nH]cc(-c4ccccc4)c3c2)cc1

nearest known ligand 0.61

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
IMPDH2 P12268 2/20 0.61
PIM1 P11309 5/20 0.57
PIM3 Q86V86 5/20 0.57
PIM2 Q9P1W9 3/20 0.57
NR4A2 P43354 2/20 0.53
AXL P30530 1/20 0.53
CDK8 P49336 1/20 0.53
TNIK Q9UKE5 1/20 0.53
HASPIN Q8TF76 1/20 0.51
DYRK1A Q13627 2/20 0.51
MAPK1 P28482 1/20 0.49
HSD17B10 Q99714 1/20 0.49
PARP1 P09874 1/20 0.48
JAK2 O60674 1/20 0.47
NPC1 O15118 1/20 0.47
MAP3K11 Q16584 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18552149 1.00 IMPDH2 (0.61) IMPDH2PIM1PIM3PIM2NR4A2
SCHEMBL24022684 1.00 IMPDH2 (0.61) IMPDH2PIM1PIM3PIM2NR4A2
SCHEMBL24022670 0.87 PIM1 (0.50) IMPDH2PIM1PIM3PIM2NR4A2
SCHEMBL18552204 0.87 PIM1 (0.49) IMPDH2PIM1PIM3PIM2NR4A2
SCHEMBL18552202 0.86 TDO2 (0.51) IMPDH2PIM1PIM3PIM2NR4A2
SCHEMBL2526465 0.84 NPC1 (0.71) IMPDH2PIM1PIM3PIM2DYRK1A
SCHEMBL18552017 0.83 NR4A2 (0.49) IMPDH2PIM1PIM3PIM2NR4A2
SCHEMBL18552020 0.83 NR4A2 (0.49) IMPDH2PIM1PIM3PIM2NR4A2
SCHEMBL12456114 0.83 PIM1 (0.46) IMPDH2PIM1PIM3PIM2NR4A2
SCHEMBL29221047 0.82 PTPN1 (0.62) IMPDH2NR4A2AXLDYRK1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104130178-A Industrialized synthesis method of medicinal indocyanine green LIAONING TIANYI BIOLOG PHARMACEUTICAL CO LTD 2014-11-05 CN claimed
US-11177443-B2 Compound and light emitting diode including same LMS CO., LTD (KR) 2021-11-16 US disclosed
WO-2017030424-A1 NOVEL COMPOUND AND LIGHT EMITTING DIODE INCLUDING SAME 주식회사 엘엠에스 2017-02-23 WO disclosed
CN-104130178-A Industrialized synthesis method of medicinal indocyanine green LIAONING TIANYI BIOLOG PHARMACEUTICAL CO LTD 2014-11-05 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11177443-B2 Compound and light emitting diode including same ARL1, ALDH1A2, DRD1 IMPDH2 2711/4885PIM1 3892/4885PIM3 3682/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.