Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | CNR2 | P34972 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | PAM | P19021 | 1/20 | 0.45 |
| ▸ | CETP | P11597 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9065264 | 0.95 | TSHR (0.49) | MEN1KMT2ATSHRCNR2MAPK1 | |
| SCHEMBL539127 | 0.83 | ALDH1A1 (0.58) | TSHRMAPK1TP53CYP3A4ALDH1A1 | |
| SCHEMBL28008659 | 0.83 | LMNA (0.53) | MEN1KMT2ATSHRMAPK1ALDH1A1 | |
| SCHEMBL28638406 | 0.83 | TDP1 (0.54) | TSHRALDH1A1LMNACETP | |
| SCHEMBL3504146 | 0.82 | ALDH1A1 (0.58) | MEN1KMT2ATSHRMAPK1TP53 | |
| SCHEMBL8089822 | 0.82 | ALDH1A1 (0.58) | MEN1KMT2ATSHRMAPK1TP53 | |
| SCHEMBL3506940 | 0.82 | ALDH1A1 (0.58) | MEN1KMT2ATSHRMAPK1TP53 | |
| SCHEMBL11580191 | 0.82 | ALDH1A1 (0.58) | MEN1KMT2ATSHRMAPK1TP53 | |
| SCHEMBL872994 | 0.82 | ALDH1A1 (0.58) | MEN1KMT2ATSHRMAPK1TP53 | |
| SCHEMBL11580968 | 0.82 | ALDH1A1 (0.58) | MEN1KMT2ATSHRMAPK1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3340979-A1 | COMPOSITIONS AND METHODS FOR DRUG SENSITIZATION OF PARASITES | The Texas A&M University System (US) | 2018-07-04 | — | — | EP | claimed |
| WO-2017035438-A1 | COMPOSITIONS AND METHODS FOR DRUG SENSITIZATION OF PARASITES | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2017-03-02 | — | — | WO | claimed |
| EP-3340979-A1 | COMPOSITIONS AND METHODS FOR DRUG SENSITIZATION OF PARASITES | The Texas A&M University System (US) | 2018-07-04 | — | — | EP | disclosed |
| WO-2017035438-A1 | COMPOSITIONS AND METHODS FOR DRUG SENSITIZATION OF PARASITES | THE TEXAS A&M UNIVERSITY SYSTEM (US) | 2017-03-02 | — | — | WO | disclosed |