Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.42 |
| ▸ | PPARG | P37231 | 4/20 | 0.42 |
| ▸ | PPARA | Q07869 | 3/20 | 0.42 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.41 |
| ▸ | PSAT1 | Q9Y617 | 1/20 | 0.41 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18554144 | 1.00 | MME (0.47) | MMEMAOBHDAC1HDAC6PPARG | |
| SCHEMBL18554221 | 0.86 | PTGES (0.42) | MMEPPARGPPARASRRPSAT1 | |
| SCHEMBL18554224 | 0.86 | PTGES (0.42) | MMEPPARGPPARASRRPSAT1 | |
| SCHEMBL18554199 | 0.85 | FFAR1 (0.53) | MMEPPARGPPARA | |
| SCHEMBL18554201 | 0.85 | FFAR1 (0.53) | MMEPPARGPPARA | |
| Hydrochloric Acid SCHEMBL18554214 | 0.84 | FFAR1 (0.51) | MMEPPARGPPARASRRPSAT1 | |
| Hydrochloric Acid SCHEMBL18554213 | 0.84 | FFAR1 (0.51) | MMEPPARGPPARASRRPSAT1 | |
| SCHEMBL18576599 | 0.81 | MME (0.45) | MMEHDAC1HDAC6PPARGPPARA | |
| SCHEMBL18554285 | 0.79 | ADRB1 (0.41) | MMEALDH1A1MAPT | |
| SCHEMBL18554307 | 0.79 | ADRB1 (0.41) | MMEALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017033128-A1 | BIPHENYL-SUBSTITUED 4-AMINO-BUTYRIC ACID DERIVATIVES AND THEIR USE IN THE SYNTHESIS OF NEP INHIBITORS | NOVARTIS AG (CH) | 2017-03-02 | — | — | WO | disclosed |
| WO-2017033128-A1 | BIPHENYL-SUBSTITUED 4-AMINO-BUTYRIC ACID DERIVATIVES AND THEIR USE IN THE SYNTHESIS OF NEP INHIBITORS | NOVARTIS AG (CH) | 2017-03-02 | — | — | WO | disclosed |