Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | PPARG | P37231 | 6/20 | 0.41 |
| ▸ | PPARA | Q07869 | 5/20 | 0.41 |
| ▸ | MME | P08473 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SRR | Q9GZT4 | 1/20 | 0.40 |
| ▸ | PSAT1 | Q9Y617 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18554224 | 1.00 | PTGES (0.42) | PTGESALOX5ALDH1A1MAPK1L3MBTL1 | |
| SCHEMBL18554144 | 0.86 | MME (0.47) | PTGESALDH1A1PPARGPPARAMME | |
| SCHEMBL18554143 | 0.86 | MME (0.47) | PTGESALDH1A1PPARGPPARAMME | |
| SCHEMBL18554199 | 0.84 | FFAR1 (0.53) | PPARGPPARAMMEFFAR1 | |
| SCHEMBL18554201 | 0.84 | FFAR1 (0.53) | PPARGPPARAMMEFFAR1 | |
| Hydrochloric Acid SCHEMBL18554214 | 0.83 | FFAR1 (0.51) | ALDH1A1PPARGPPARAMMEMAPT | |
| Hydrochloric Acid SCHEMBL18554213 | 0.83 | FFAR1 (0.51) | ALDH1A1PPARGPPARAMMEMAPT | |
| SCHEMBL13240730 | 0.77 | ALDH1A1 (0.49) | ALDH1A1MAPK1L3MBTL1MEN1KMT2A | |
| SCHEMBL22444011 | 0.77 | ALDH1A1 (0.49) | ALDH1A1MAPK1L3MBTL1MEN1KMT2A | |
| SCHEMBL18554287 | 0.76 | NAAA (0.57) | ALDH1A1MAPK1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017033128-A1 | BIPHENYL-SUBSTITUED 4-AMINO-BUTYRIC ACID DERIVATIVES AND THEIR USE IN THE SYNTHESIS OF NEP INHIBITORS | NOVARTIS AG (CH) | 2017-03-02 | — | — | WO | disclosed |
| WO-2017033128-A1 | BIPHENYL-SUBSTITUED 4-AMINO-BUTYRIC ACID DERIVATIVES AND THEIR USE IN THE SYNTHESIS OF NEP INHIBITORS | NOVARTIS AG (CH) | 2017-03-02 | — | — | WO | disclosed |