Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CTSH | P09668 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 1/20 | 0.47 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.45 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.45 |
| ▸ | MRE11 | P49959 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | MME | P08473 | 1/20 | 0.41 |
| ▸ | PRCP | P42785 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20474596 | 1.00 | CTSC (0.48) | CTSCCYP1A2CYP3A4CTSHCYP2D6 | |
| SCHEMBL20474574 | 0.82 | CTSC (0.45) | CTSCCYP1A2CYP3A4CTSHCYP2D6 | |
| SCHEMBL18554073 | 0.82 | CTSC (0.45) | CTSCCYP1A2CYP3A4CTSHCYP2D6 | |
| SCHEMBL20474581 | 0.81 | ROCK2 (0.52) | ITGB1ITGA4OPRK1 | |
| SCHEMBL18554064 | 0.81 | ROCK2 (0.52) | ITGB1ITGA4OPRK1 | |
| SCHEMBL20474555 | 0.80 | MMP2 (0.46) | OPRD1OPRM1OPRK1MMEPRCP | |
| SCHEMBL18554058 | 0.80 | MMP2 (0.46) | OPRD1OPRM1OPRK1MMEPRCP | |
| SCHEMBL12377253 | 0.79 | CTSC (0.59) | CTSCCYP1A2CYP3A4CTSHCYP2D6 | |
| SCHEMBL18554025 | 0.79 | CTSC (0.59) | CTSCCYP1A2CYP3A4CTSHCYP2D6 | |
| SCHEMBL3178122 | 0.77 | CYP19A1 (0.51) | CYP1A2CTSKMMECYP19A1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240415830-A1 | COMPOSITION AND METHODS OF USE OF NOVEL PHENYLALANINE SMALL ORGANIC COMPOUNDS TO DIRECTLY MODULATE PCSK9 PROTEIN ACTIVITY | SRX CARDIO LLC (US) | 2024-12-19 | — | — | US | claimed |
| US-11944619-B2 | Phenylalanine small organic compounds to directly modulate PCSK9 protein activity | SRX CARDIO, LLC (US) | 2024-04-02 | — | — | US | claimed |
| EP-3337497-B1 | COMPOSITION AND METHODS OF USE OF NOVEL PHENYLALANINE SMALL ORGANIC COMPOUNDS TO DIRECTLY MODULATE PCSK9 PROTEIN ACTIVITY | SRX CARDIO LLC (US) | 2023-07-12 | — | — | EP | claimed |
| US-20210236481-A1 | COMPOSITION AND METHODS OF USE OF NOVEL PHENYLALANINE SMALL ORGANIC COMPOUNDS TO DIRECTLY MODULATE PCSK9 PROTEIN ACTIVITY | SRX CARDIO, LLC | 2021-08-05 | — | — | US | claimed |
| US-10821106-B2 | Composition and methods of use of novel phenylalanine small organic compounds to directly modulate PCSK9 protein activity | SRX CARDIO, LLC | 2020-11-03 | — | — | US | claimed |
| US-20240415830-A1 | COMPOSITION AND METHODS OF USE OF NOVEL PHENYLALANINE SMALL ORGANIC COMPOUNDS TO DIRECTLY MODULATE PCSK9 PROTEIN ACTIVITY | SRX CARDIO LLC (US) | 2024-12-19 | — | — | US | disclosed |
| US-11944619-B2 | Phenylalanine small organic compounds to directly modulate PCSK9 protein activity | SRX CARDIO, LLC (US) | 2024-04-02 | — | — | US | disclosed |
| EP-3337497-B1 | COMPOSITION AND METHODS OF USE OF NOVEL PHENYLALANINE SMALL ORGANIC COMPOUNDS TO DIRECTLY MODULATE PCSK9 PROTEIN ACTIVITY | SRX CARDIO LLC (US) | 2023-07-12 | — | — | EP | disclosed |
| US-20210236481-A1 | COMPOSITION AND METHODS OF USE OF NOVEL PHENYLALANINE SMALL ORGANIC COMPOUNDS TO DIRECTLY MODULATE PCSK9 PROTEIN ACTIVITY | SRX CARDIO, LLC | 2021-08-05 | — | — | US | disclosed |
| US-10821106-B2 | Composition and methods of use of novel phenylalanine small organic compounds to directly modulate PCSK9 protein activity | SRX CARDIO, LLC | 2020-11-03 | — | — | US | disclosed |
| US-20180237381-A1 | COMPOSITION AND METHODS OF USE OF NOVEL PHENYLALANINE SMALL ORGANIC COMPOUNDS TO DIRECTLY MODULATE PCSK9 PROTEIN ACTIVITY | SRX CARDIO, LLC | 2018-08-23 | — | — | US | disclosed |
| EP-3337497-A1 | COMPOSITION AND METHODS OF USE OF NOVEL PHENYLALANINE SMALL ORGANIC COMPOUNDS TO DIRECTLY MODULATE PCSK9 PROTEIN ACTIVITY | Portola Pharmaceuticals, Inc. (US) | 2018-06-27 | — | — | EP | disclosed |
| WO-2017034994-A1 | COMPOSITION AND METHODS OF USE OF NOVEL PHENYLALANINE SMALL ORGANIC COMPOUNDS TO DIRECTLY MODULATE PCSK9 PROTEIN ACTIVITY | PORTOLA PHARMACEUTICALS, INC. (US) | 2017-03-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11944619-B2 | Phenylalanine small organic compounds to directly modulate PCSK9 protein activity | PCSK9, LDLR, APOL1 | CTSC 172/4885CYP1A2 921/4885CYP3A4 487/4885 |
| US-10821106-B2 | Composition and methods of use of novel phenylalanine small organic compounds to directly modulate PCSK9 protein activity | PCSK9, LDLR, APOB | CTSC 143/4885CYP1A2 1280/4885CYP3A4 916/4885 |
| US-20210236481-A1 | COMPOSITION AND METHODS OF USE OF NOVEL PHENYLALANINE SMALL ORGANIC COMPOUNDS TO DIRECTLY MODULATE PCSK9 PROTEIN ACTIVITY | PCSK9, LDLR, APOB | CTSC 143/4885CYP1A2 1280/4885CYP3A4 916/4885 |
| US-20180237381-A1 | COMPOSITION AND METHODS OF USE OF NOVEL PHENYLALANINE SMALL ORGANIC COMPOUNDS TO DIRECTLY MODULATE PCSK9 PROTEIN ACTIVITY | PCSK9, LDLR, APOB | CTSC 143/4885CYP1A2 1280/4885CYP3A4 916/4885 |
| US-20240415830-A1 | COMPOSITION AND METHODS OF USE OF NOVEL PHENYLALANINE SMALL ORGANIC COMPOUNDS TO DIRECTLY MODULATE PCSK9 PROTEIN ACTIVITY | PCSK9, LDLR, APOB | CTSC 143/4885CYP1A2 1280/4885CYP3A4 916/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.