Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.51 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.51 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.51 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.49 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.49 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.49 |
| ▸ | TYK2 | P29597 | 1/20 | 0.49 |
| ▸ | CLK2 | P49760 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | STK32B | Q9NY57 | 1/20 | 0.49 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.49 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.49 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1854301 | 0.99 | PIM1 (0.50) | PIM1PIM3PIM2BMPR1BPIK3C2G | |
| SCHEMBL1853610 | 0.82 | NPC1 (0.54) | DYRK1API4KBKMT2AMAPTMEN1 | |
| Hydrochloric Acid SCHEMBL1852223 | 0.81 | NPC1 (0.53) | DYRK1API4KBKMT2AMAPTMEN1 | |
| SCHEMBL17179205 | 0.75 | PIM1 (0.60) | PIM1PIM3PIM2BMPR1BPIK3C2G | |
| SCHEMBL16068645 | 0.74 | ALDH1A1 (0.53) | CLK2DYRK1AKMT2AGAAMAPT | |
| Ether SCHEMBL1864755 | 0.73 | MAPT (0.44) | DYRK1API4KBMAPTPOLBPIK3CA | |
| SCHEMBL2772360 | 0.72 | PDGFRB (0.77) | NISCHPDGFRBPDGFRACYP2A6MAPT | |
| SCHEMBL32667946 | 0.72 | PDGFRB (0.77) | NISCHPDGFRBPDGFRACYP2A6MAPT | |
| SCHEMBL1854414 | 0.72 | PDGFRB (0.49) | PIM1PIM3PIM2BMPR1BPIK3C2G | |
| SCHEMBL16200195 | 0.71 | PDGFRB (0.49) | PIM1PIM3PIM2BMPR1BPIK3C2G |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2323988-A1 | ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITORS | Wyeth LLC (US) | 2011-05-25 | — | — | EP | disclosed |
| US-20100130474-A1 | ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITORS | WYETH (US) | 2010-05-27 | — | — | US | disclosed |
| WO-2010009290-A1 | ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITORS | WYETH (US) | 2010-01-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130474-A1 | ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITORS | CHRNA7, CHRNA6, CHRNA2 | PIM1 4716/4885PIM3 4472/4885PIM2 4602/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.