Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.42 |
| ▸ | MME | P08473 | 8/20 | 0.42 |
| ▸ | ACE | P12821 | 8/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.39 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.39 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.39 |
| ▸ | ALB | P02768 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | RARB | P10826 | 1/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18557270 | 1.00 | REN (0.42) | RENMMEACENPC1RAB9A | |
| SCHEMBL27665604 | 0.84 | KMT2A (0.45) | MMEACETBXAS1 | |
| SCHEMBL15134787 | 0.82 | MME (0.44) | MMEACENPC1RAB9ATBXAS1 | |
| SCHEMBL15865877 | 0.82 | MME (0.44) | MMEACENPC1RAB9ATBXAS1 | |
| SCHEMBL15568884 | 0.81 | TBXAS1 (0.51) | MMENPC1RAB9ATBXAS1PTGS1 | |
| SCHEMBL12200630 | 0.81 | TBXAS1 (0.51) | MMENPC1RAB9ATBXAS1PTGS1 | |
| SCHEMBL15134789 | 0.81 | TBXAS1 (0.51) | MMENPC1RAB9ATBXAS1PTGS1 | |
| SCHEMBL12879843 | 0.81 | ENPEP (0.49) | MMEACENPC1RAB9ATBXAS1 | |
| SCHEMBL12873867 | 0.81 | ENPEP (0.49) | MMEACENPC1RAB9ATBXAS1 | |
| SCHEMBL15134788 | 0.81 | ENPEP (0.49) | MMEACENPC1RAB9ATBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9580467-B2 | Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof | E. R. SQUIBB & SONS, L.L.C. (US) | 2017-02-28 | — | — | US | disclosed |