Sugi Predict

Sugi Predict / Compounds / SCHEMBL18558016

SCHEMBL18558016

SCHEMBL18558016

CCCCC(C(=O)NC(Cc1ccccc1)C(=O)O)C(C)(C)C

nearest known ligand 0.61

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ MMP1 P03956 5/20 0.61
▸ MMP3 P08254 5/20 0.61
▸ MME P08473 7/20 0.61
▸ ACE P12821 6/20 0.61
▸ CPA1 P15085 6/20 0.61
▸ ACE2 Q9BYF1 6/20 0.61
▸ MMP2 P08253 9/20 0.52
▸ GNPAT O15228 1/20 0.52
▸ HDAC3 O15379 1/20 0.51
▸ HDAC4 P56524 1/20 0.51
▸ HDAC1 Q13547 1/20 0.51
▸ HDAC2 Q92769 1/20 0.51
▸ HDAC8 Q9BY41 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29232996 0.87 MME (0.67) MMP1MMP3MMEACECPA1
SCHEMBL4242808 0.84 MME (0.64) MMP1MMP3MMEACECPA1
SCHEMBL5966735 0.84 MME (0.64) MMP1MMP3MMEACECPA1
SCHEMBL13427629 0.83 MME (0.65) MMP1MMP3MMEACECPA1
SCHEMBL16601898 0.82 MMP2 (0.62) MMP1MMP3MMEACECPA1
SCHEMBL9956195 0.82 MME (0.64) MMEACECPA1ACE2GNPAT
SCHEMBL30973624 0.82 MME (0.64) MMEACECPA1ACE2GNPAT
SCHEMBL8583007 0.82 MME (0.64) MMEACECPA1ACE2GNPAT
SCHEMBL16601895 0.82 MMP2 (0.62) MMP1MMP3MMEACECPA1
SCHEMBL30866238 0.80 GNPAT (0.72) MMP1MMP3MMEACECPA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220202777-A1 AMIDE DERIVATIVES OF N-UREA SUBSTITUTED AMINO ACIDS AS FORMYL PEPTIDE RECEPTOR LIKE-1 (FPRL-1) RECEPTOR MODULATORS ALLERGAN, INC. 2022-06-30 — — US disclosed
US-10172832-B2 Amide derivatives of N-urea substituted amino acids as formyl peptide receptor like-1 (FPRL-1) receptor modulators ALLERGAN, INC. (US) 2019-01-08 — — US disclosed
US-9974772-B2 Amide derivatives of N-urea substituted amino acids as formyl peptide receptor like-1 (FPRL-1) receptor modulators ALLERGAN, INC. (US) 2018-05-22 — — US disclosed
US-20170119737-A1 AMIDE DERIVATIVES OF N-UREA SUBSTITUTED AMINO ACIDS AS FORMYL PEPTIDE RECEPTOR LIKE-1 (FPRL-1) RECEPTOR MODULATORS ALLERGAN, INC. 2017-05-04 — — US disclosed
US-9579307-B2 Amide derivatives of N-urea substituted amino acids as formyl peptide receptor like-1 (FPRL-1) receptor modulators ALLERGAN, INC. (US) 2017-02-28 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170119737-A1 AMIDE DERIVATIVES OF N-UREA SUBSTITUTED AMINO ACIDS AS FORMYL PEPTIDE RECEPTOR LIKE-1 (FPRL-1) RECEPTOR MODULATORS FPR1, FPR3, FPR2 MMP1 4416/4885MMP3 4640/4885MME 555/4885
US-10172832-B2 Amide derivatives of N-urea substituted amino acids as formyl peptide receptor like-1 (FPRL-1) receptor modulators FPR1, FPR3, FPR2 MMP1 4416/4885MMP3 4640/4885MME 555/4885
US-20220202777-A1 AMIDE DERIVATIVES OF N-UREA SUBSTITUTED AMINO ACIDS AS FORMYL PEPTIDE RECEPTOR LIKE-1 (FPRL-1) RECEPTOR MODULATORS FPR1, FPR3, FPR2 MMP1 4416/4885MMP3 4640/4885MME 555/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.