Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 2/20 | 0.36 |
| ▸ | GRM5 | P41594 | 2/20 | 0.36 |
| ▸ | RAF1 | P04049 | 2/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18558387 | 0.93 | RAF1 (0.41) | MAPTHDAC6ALPLCNR2GRM5 | |
| SCHEMBL18558156 | 0.91 | MAPT (0.36) | MAPTHDAC6ALPLCNR2GRM5 | |
| SCHEMBL18558126 | 0.91 | RAB9A (0.38) | MAPTTP53ALPLCNR2GRM5 | |
| SCHEMBL18558394 | 0.91 | RAF1 (0.39) | HDAC6ALPLCNR2RAF1BCHE | |
| SCHEMBL18558653 | 0.90 | IDO1 (0.39) | HDAC6ALPLIDO1 | |
| SCHEMBL19360275 | 0.90 | MAPT (0.39) | MAPTTP53HDAC6ALPLRAF1 | |
| SCHEMBL18558154 | 0.90 | GRM5 (0.42) | HDAC6ALPLCNR2GRM5RAF1 | |
| SCHEMBL18557825 | 0.90 | ALPL (0.38) | HDAC6ALPLCNR2GRM5RAF1 | |
| SCHEMBL18558155 | 0.89 | MAPT (0.41) | MAPTTP53HDAC6ALPL | |
| SCHEMBL18557830 | 0.89 | MAPT (0.41) | MAPTTP53HDAC6ALPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9580388-B2 | Pyrazolyl guanidine F1F0-ATPase inhibitors and therapeutic uses thereof | LYCERA CORPORATION (US) | 2017-02-28 | — | — | US | disclosed |