Sugi Predict

Sugi Predict / Compounds / SCHEMBL1855857

SCHEMBL1855857

SCHEMBL1855857

Brc1cccc2cn[nH]c12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NOS1 P29475 6/20 1.00
▸ MAPT P10636 2/20 0.50
▸ HSD17B10 Q99714 2/20 0.50
▸ TDP1 Q9NUW8 2/20 0.50
▸ PLK4 O00444 1/20 0.50
▸ CHEK1 O14757 1/20 0.50
▸ AURKA O14965 1/20 0.50
▸ DAPK3 O43293 1/20 0.50
▸ MAP4K4 O95819 1/20 0.50
▸ CSF1R P07333 1/20 0.50
▸ RET P07949 1/20 0.50
▸ FGFR1 P11362 1/20 0.50
▸ PDGFRA P16234 1/20 0.50
▸ LTK P29376 1/20 0.50
▸ KDR P35968 1/20 0.50
▸ MAP2K2 P36507 1/20 0.50
▸ FLT3 P36888 1/20 0.50
▸ CSNK1A1 P48729 1/20 0.50
▸ PRKX P51817 1/20 0.50
▸ CDK5 Q00535 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10595713 0.79 NOS1 (0.65) NOS1MAPTHSD17B10TDP1PLK4
SCHEMBL3064844 0.77 NOS1 (0.63) NOS1MAPTHSD17B10TDP1PLK4
SCHEMBL14231151 0.76 NOS1 (0.61) NOS1MAPTHSD17B10TDP1PLK4
SCHEMBL11577370 0.75 NOS1 (0.60) NOS1MAPTHSD17B10TDP1PLK4
SCHEMBL104360 0.74 NOS1 (1.00) NOS1MAPTHSD17B10TDP1PLK4
SCHEMBL655480 0.74 NOS1 (0.59) NOS1MAPTHSD17B10TDP1PLK4
SCHEMBL2008172 0.74 NOS1 (0.59) NOS1MAPTHSD17B10TDP1PLK4
SCHEMBL1911926 0.74 NOS1 (0.59) NOS1MAPTHSD17B10TDP1PLK4
SCHEMBL276868 0.74 NOS1 (0.59) NOS1MAPTHSD17B10TDP1PLK4
SCHEMBL12930782 0.74 NOS1 (0.59) NOS1MAPTHSD17B10TDP1PLK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 270 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260109670-A1 METHOD FOR ARYL DEBROMINATION AND ACYLATION OF BROMINATED BENZO-FUSED NITROGEN HETEROCYCLE Shanghai OuChem Bio-Technology Co., LTD (CN) 2026-04-23 — — US claimed
CN-116046922-B Method for measuring content of 7-bromo-1-H-indazole by high performance liquid chromatography 山东阳谷华泰化工股份有限公司 2025-04-25 — — CN claimed
CN-119059958-A Method for aryl debromination acylation of bromobenzazepine compounds 上海沃凯生物技术有限公司 2024-12-03 — — CN claimed
CN-118546092-A Synthesis method of 7-bromo-1H-indazole-3-methyl formate 南通大学 2024-08-27 — — CN claimed
WO-2023122498-A1 ONE-STEP OXIDE BATH FOR IMPROVING ADHESION OF POLYMERIC MATERIALS TO METAL SUBSTRATES MACDERMID, INCORPORATED (US) 2023-06-29 — — WO claimed
US-20230199972-A1 One-Step Oxide Bath for Improving Adhesion of Polymeric Materials to Metal Substrates MACDERMID, INCORPORATED 2023-06-22 — — US claimed
CN-116046922-A Method for measuring content of 7-bromo-1-H-indazole by high performance liquid chromatography 山东阳谷华泰化工股份有限公司 2023-05-02 — — CN claimed
CN-109887764-B Electrolyte of high-nickel ternary system capacitor battery and preparation method thereof 无锡凯帕德瑞科技有限公司 2021-06-25 — — CN claimed
CN-109887764-A The electrolyte and preparation method thereof of nickelic ternary system capacitor batteries 无锡凯帕德瑞科技有限公司 2019-06-14 — — CN claimed
CN-109180736-A Rhodium (III) complex and its preparation method and application for treating gastric cancer 广西中医药大学 2019-01-11 — — CN claimed
CN-109134549-A Iridium (III) complex and its preparation method and application for treating gastric cancer 广西中医药大学 2019-01-04 — — CN claimed
CN-109021028-A Organic ruthenium complex and preparation method thereof and application in preparation of anti-tumor drugs 广西中医药大学 2018-12-18 — — CN claimed
CN-109021029-A Compound and its preparation method and application for treating gastric cancer 广西中医药大学 2018-12-18 — — CN claimed
CN-108864202-A Compound and its preparation method and application for treating liver cancer 广西中医药大学 2018-11-23 — — CN claimed
EP-4747260-A1 MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE F. Hoffmann-La Roche AG (CH) 2026-05-27 — — EP disclosed
US-12637471-B2 Heterocyclic compounds, compositions, methods of preparation and uses thereof ORGANON R&D FINLAND LTD. (FI) 2026-05-26 — — US disclosed
CN-122070287-A IRAK 4-targeted degradation agent compound and application thereof 江苏先声药业有限公司 2026-05-19 — — CN disclosed
US-20040110815-A1 Indazole derivatives as CRF antagonists ROCHE PALO ALTO LLC 2004-06-10 — — US disclosed
US-4096333-A NITROSATION OF A 2-METHYLACETANILIDE TENNECO CHEMICALS, INC. (US) 1978-06-20 — — US disclosed
US-3988347-A NITROSATION OF A 2-METHYL-ACETANILIDE WITH SODIUM NITRITE TENNECO CHEMICALS, INC. (US) 1976-10-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040110815-A1 Indazole derivatives as CRF antagonists CRHR1, CRHR2, ARRB1 NOS1 1868/4885MAPT 3725/4885HSD17B10 2761/4885
US-20260109670-A1 METHOD FOR ARYL DEBROMINATION AND ACYLATION OF BROMINATED BENZO-FUSED NITROGEN HETEROCYCLE NAT1, AADAC, NAA15 NOS1 496/4885MAPT 4076/4885HSD17B10 138/4885
US-12637471-B2 Heterocyclic compounds, compositions, methods of preparation and uses thereof AKR1C3, AKR1C4, AKR1C2 NOS1 2196/4885MAPT 4581/4885HSD17B10 25/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.