Sugi Predict

Sugi Predict / Compounds / SCHEMBL276869

SCHEMBL276869

SCHEMBL276869

Oc1cccc2cn[nH]c12

nearest known ligand 0.59

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NOS1 P29475 3/20 0.59
▸ PLK4 O00444 1/20 0.55
▸ CHEK1 O14757 1/20 0.55
▸ AURKA O14965 1/20 0.55
▸ DAPK3 O43293 1/20 0.55
▸ MAP4K4 O95819 1/20 0.55
▸ CSF1R P07333 1/20 0.55
▸ RET P07949 1/20 0.55
▸ FGFR1 P11362 1/20 0.55
▸ PDGFRA P16234 1/20 0.55
▸ LTK P29376 1/20 0.55
▸ KDR P35968 1/20 0.55
▸ MAP2K2 P36507 1/20 0.55
▸ FLT3 P36888 1/20 0.55
▸ CSNK1A1 P48729 1/20 0.55
▸ PRKX P51817 1/20 0.55
▸ CDK5 Q00535 1/20 0.55
▸ MAP2K1 Q02750 1/20 0.55
▸ MST1R Q04912 1/20 0.55
▸ PTK2 Q05397 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30061113 1.00 NOS1 (0.59) NOS1PLK4CHEK1AURKADAPK3
SCHEMBL10593110 0.79 NOS1 (0.46) NOS1PLK4CHEK1AURKADAPK3
SCHEMBL3064844 0.77 NOS1 (0.63) NOS1PLK4CHEK1AURKADAPK3
SCHEMBL14231151 0.76 NOS1 (0.61) NOS1PLK4CHEK1AURKADAPK3
SCHEMBL16720813 0.75 NOS1 (0.42) NOS1PLK4CHEK1AURKADAPK3
SCHEMBL1911926 0.74 NOS1 (0.59) NOS1PLK4CHEK1AURKADAPK3
SCHEMBL2008172 0.74 NOS1 (0.59) NOS1PLK4CHEK1AURKADAPK3
SCHEMBL276868 0.74 NOS1 (0.59) NOS1PLK4CHEK1AURKADAPK3
SCHEMBL655480 0.74 NOS1 (0.59) NOS1PLK4CHEK1AURKADAPK3
SCHEMBL8995871 0.74 MAPT (0.46) NOS1PLK4CHEK1AURKADAPK3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 136 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105734586-B A kind of organic-silicon-modified corrosion inhibitor and preparation method thereof 中国石油化工股份有限公司 2018-04-10 — — CN claimed
WO-2016154694-A1 N-ACYLHYDRAZONE COMPOUNDS INHIBITING HISTONE DESACETYLASE ENZYMES, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND METHOD FOR PRODUCING SAME UNIVERSIDADE FEDERAL DO RIO DE JANEIRO-UFRJ (BR) 2016-10-06 — — WO claimed
CN-105734586-A Organosilicon-modified corrosion inhibitor and preparation method thereof 中国石油化工股份有限公司 2016-07-06 — — CN claimed
CN-103370321-B Kui Linpyrimido quinoline [1, the 2-b] indazole replaced and the purposes of the conditioning agent as PI3K/AKT approach thereof BAYER INTELLECTUAL PROPERTY GMBH (DE) 2015-07-29 — — CN claimed
WO-2007071686-A1 COMPOSITION FOR DYEING KERATIN FIBRES WITH A TETRAAZAPENTAMETHINE CATIONIC DIRECT DYE, AN OXIDATION BASE AND A PARTICULAR COUPLER L'ORÉAL (FR) 2007-06-28 — — WO claimed
US-20040231067-A1 Dyeing composition comprising a cationic tertiary para-phenylenediamine and heterocyclic coupler, methods and uses L'OREAL (FR) 2004-11-25 — — US claimed
EP-1428510-A1 Dyeing composition comprising a tertiary paraphenylenediamine containing a pyrrolidine, and a heterocyclic coupler or a hydroxybenzamide ; method and use L'OREAL (FR) 2004-06-16 — — EP claimed
US-12583858-B2 TDO2 inhibitors GENENTECH, INC. (US) 2026-03-24 — — US disclosed
US-12522595-B2 Bicyclic ether O-glycoprotein-2-acetamido-2-deoxy-3-D-glucopyranosidase inhibitors BIOGEN MA INC. (US) 2026-01-13 — — US disclosed
EP-3394068-B1 TDO2 INHIBITORS GENENTECH INC (US) 2024-09-11 — — EP disclosed
US-20240239794-A1 PKC-Theta Modulators EXSCIENTIA AI LIMITED (GB) 2024-07-18 — — US disclosed
US-20240239794-A1 PKC-Theta Modulators EXSCIENTIA AI LIMITED (GB) 2024-07-18 — — US disclosed
CN-117295738-A PKC-theta modulators 爱智药人工智能有限公司 2023-12-26 — — CN disclosed
US-4507488-A N-Pyrazolylalkylenediamine intermediates BOEHRINGER MANNHEIM GMBH (DE) 1985-03-26 — — US disclosed
EP-0042592-B1 N-HETEROARYLALKYLENE DIAMINES, PROCESS FOR THEIR PREPARATION AND THEIR USE Roche Diagnostics GmbH (DE) 1985-01-30 — — EP disclosed
US-4438128-A ADRENERGIC BLOCKERS BOEHRINGER MANNHEIM GMBH (DE) 1984-03-20 — — US disclosed
EP-0042592-A1 N-heteroarylalkylene diamines, process for their preparation and their use Roche Diagnostics GmbH (DE) 1981-12-30 — — EP disclosed
EP-0042593-A1 Aryloxy-propanol amines, process for their preparation and medicines containing these compounds Roche Diagnostics GmbH (DE) 1981-12-30 — — EP disclosed
US-4168953-A Oxidation hair dyes based upon tetraaminopyrimidine developers and monohydroxyindazole couplers HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KGAA) (DE) 1979-09-25 — — US disclosed
US-3939084-A Functional fluid compositions containing substituted pyrimidines MONSANTO COMPANY (US) 1976-02-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12583858-B2 TDO2 inhibitors TDO2, IDO2, TPH2 NOS1 1079/4885PLK4 3719/4885CHEK1 2230/4885
US-20240239794-A1 PKC-Theta Modulators PRKCQ, PRKCH, PRKCZ NOS1 1460/4885PLK4 1030/4885CHEK1 887/4885
US-20040231067-A1 Dyeing composition comprising a cationic tertiary para-phenylenediamine and heterocyclic coupler, methods and uses KRT18, CDC73, PYCR1 NOS1 2710/4885PLK4 1124/4885CHEK1 1129/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.