Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 2/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 5/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.33 |
| ▸ | VNN1 | O95497 | 1/20 | 0.33 |
| ▸ | TTK | P33981 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | STK4 | Q13043 | 1/20 | 0.31 |
| ▸ | METAP2 | P50579 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | CTSL | P07711 | 1/20 | 0.30 |
| ▸ | CTSB | P07858 | 1/20 | 0.30 |
| ▸ | CTSS | P25774 | 1/20 | 0.30 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL200796 | 0.92 | FAAH (0.33) | BDKRB1FAAHTRPV1VNN1GRM5 | |
| SCHEMBL2809766 | 0.90 | BDKRB1 (0.43) | BDKRB1PIM2VNN1TTKCTSL | |
| SCHEMBL185311 | 0.88 | BDKRB1 (0.37) | BDKRB1FAAHTRPV1 | |
| SCHEMBL2806859 | 0.82 | BDKRB1 (0.40) | BDKRB1VNN1CTSLCTSS | |
| SCHEMBL202538 | 0.81 | BDKRB1 (0.38) | BDKRB1FAAHTRPV1VNN1TTK | |
| SCHEMBL14856605 | 0.80 | FAAH (0.35) | BDKRB1FAAHTRPV1NTRK1 | |
| SCHEMBL2805300 | 0.78 | BDKRB1 (0.44) | BDKRB1CTSLCTSBCTSS | |
| SCHEMBL196872 | 0.78 | BDKRB1 (0.40) | BDKRB1FAAHTRPV1VNN1CTSL | |
| SCHEMBL14857250 | 0.78 | BDKRB1 (0.40) | BDKRB1FAAHTRPV1CTSLCTSB | |
| SCHEMBL2805260 | 0.77 | BDKRB1 (0.45) | BDKRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |