Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 2/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | VNN1 | O95497 | 1/20 | 0.33 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.32 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL185655 | 0.92 | BDKRB1 (0.35) | FAAHTRPV1VNN1BDKRB1GRM5 | |
| SCHEMBL2806859 | 0.90 | BDKRB1 (0.40) | VNN1BDKRB1CXCR4LRRK2CHEK1 | |
| SCHEMBL186484 | 0.84 | BDKRB1 (0.40) | BDKRB1 | |
| SCHEMBL14857200 | 0.84 | BDKRB1 (0.40) | BDKRB1 | |
| SCHEMBL202538 | 0.82 | BDKRB1 (0.38) | FAAHTRPV1VNN1BDKRB1CXCR4 | |
| SCHEMBL2809766 | 0.82 | BDKRB1 (0.43) | VNN1BDKRB1CXCR4 | |
| SCHEMBL14857219 | 0.81 | CHRM4 (0.36) | FAAHTRPV1BDKRB1LRRK2CHEK1 | |
| SCHEMBL185311 | 0.80 | BDKRB1 (0.37) | FAAHTRPV1BDKRB1 | |
| SCHEMBL200841 | 0.80 | CHRM4 (0.35) | FAAHTRPV1VNN1LRRK2CHEK1 | |
| SCHEMBL202870 | 0.80 | CHRM4 (0.39) | FAAHTRPV1VNN1BDKRB1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |