Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 9/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 2/20 | 0.35 |
| ▸ | FAAH | O00519 | 5/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2805300 | 0.90 | BDKRB1 (0.44) | BDKRB1CNR1ARP2RX7AURKA | |
| SCHEMBL185655 | 0.88 | BDKRB1 (0.35) | BDKRB1FAAHTRPV1 | |
| SCHEMBL202538 | 0.81 | BDKRB1 (0.38) | BDKRB1ARFAAHTRPV1 | |
| SCHEMBL200796 | 0.80 | FAAH (0.33) | BDKRB1FAAHTRPV1 | |
| SCHEMBL196872 | 0.80 | BDKRB1 (0.40) | BDKRB1FAAHTRPV1 | |
| SCHEMBL14857250 | 0.80 | BDKRB1 (0.40) | BDKRB1FAAHTRPV1 | |
| SCHEMBL2809766 | 0.77 | BDKRB1 (0.43) | BDKRB1CNR1ARAURKA | |
| SCHEMBL14857225 | 0.77 | BDKRB1 (0.38) | BDKRB1TRPV1 | |
| SCHEMBL185883 | 0.77 | FAAH (0.42) | BDKRB1CNR1FAAHTRPV1P2RX7 | |
| SCHEMBL2836906 | 0.76 | BDKRB1 (0.54) | BDKRB1CNR1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |