Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | RXRA | P19793 | 2/20 | 0.43 |
| ▸ | RXRB | P28702 | 2/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14473046 | 0.88 | CA1 (0.53) | TSHRHSD17B10ALDH1A1CA1CA2 | |
| SCHEMBL18697467 | 0.86 | TSHR (0.45) | TSHRHSD17B10ALDH1A1CA1CA2 | |
| SCHEMBL5495923 | 0.85 | CA1 (0.50) | TSHRHSD17B10ALDH1A1CA1CA2 | |
| SCHEMBL982170 | 0.80 | CA1 (0.52) | TSHRHSD17B10ALDH1A1CA1CA2 | |
| SCHEMBL18560516 | 0.79 | ALDH1A1 (0.42) | ALDH1A1KMT2ASMN1; SMN2PPARGPPARA | |
| SCHEMBL18515332 | 0.79 | NR4A2 (0.46) | TSHRHSD17B10ALDH1A1CA1CA2 | |
| SCHEMBL19415089 | 0.79 | KDM2B (0.44) | ALDH1A1KMT2AMAPK1NPC1POLB | |
| SCHEMBL11693473 | 0.77 | RXRA (0.53) | TSHRHSD17B10CA1CA2RXRA | |
| SCHEMBL20627946 | 0.76 | MAPT (0.46) | HSD17B10ALDH1A1KMT2AMAPK1POLB | |
| SCHEMBL322440 | 0.75 | CA1 (0.59) | TSHRHSD17B10ALDH1A1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2637699-B1 | DOUBLE-ACYLATED GLP-1 DERIVATIVES WITH A LINKER | NOVO NORDISK AS (DK) | 2018-05-16 | — | — | EP | disclosed |
| EP-2846824-B1 | DOUBLE-ACYLATED GLP-1 DERIVATIVES | NOVO NORDISK AS (DK) | 2017-04-05 | — | — | EP | disclosed |
| EP-2753642-B1 | GLP-1 DERIVATIVES | NOVO NORDISK AS (DK) | 2017-03-01 | — | — | EP | disclosed |