Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB1 | P46663 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.33 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 2/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.32 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MYC | P01106 | 1/20 | 0.32 |
| ▸ | MAX | P61244 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2806861 | 0.85 | SMN1; SMN2 (0.40) | BDKRB1MEN1CYP1A2KMT2AP2RX7 | |
| SCHEMBL186029 | 0.80 | CTDSP1 (0.33) | MEN1CYP1A2KMT2AP2RX7SSTR4 | |
| SCHEMBL2806172 | 0.79 | POLB (0.43) | MEN1CYP1A2KMT2AP2RX7SSTR4 | |
| SCHEMBL198810 | 0.78 | SMN1; SMN2 (0.38) | MEN1CYP1A2KMT2AP2RX7SSTR4 | |
| SCHEMBL2804900 | 0.78 | SMN1; SMN2 (0.38) | MEN1CYP1A2KMT2AP2RX7SSTR4 | |
| SCHEMBL185594 | 0.78 | SMN1; SMN2 (0.38) | MEN1CYP1A2KMT2AP2RX7SSTR4 | |
| SCHEMBL185966 | 0.78 | BDKRB1 (0.40) | BDKRB1MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL2806680 | 0.78 | RAB9A (0.39) | BDKRB1MEN1KMT2AP2RX7CYP3A4 | |
| SCHEMBL2807722 | 0.76 | CTSL (0.44) | BDKRB1MEN1KMT2AMT-CO2PTK2 | |
| SCHEMBL2809250 | 0.76 | ALDH1A1 (0.41) | BDKRB1MEN1CYP1A2KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |