SCHEMBL1857628

SCHEMBL1857628

CCOC(=O)C#CC(=O)O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.43
LMNA P02545 1/20 0.42
HSD17B10 Q99714 1/20 0.42
ALOX15 P16050 1/20 0.40
MGAM O43451 1/20 0.40
GAA P10253 1/20 0.40
SI P14410 1/20 0.40
MGAM2 Q2M2H8 1/20 0.40
SOAT1 P35610 1/20 0.40
HCAR2 Q8TDS4 1/20 0.38
TRPA1 O75762 1/20 0.37
TSHR P16473 2/20 0.35
CYP2D6 P10635 2/20 0.34
EGLN1 Q9GZT9 1/20 0.34
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
NPC1 O15118 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
GLO1 Q04760 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18446 0.89 ALDH1A1 (0.53) ALDH1A1LMNAHSD17B10ALOX15MGAM
SCHEMBL16811766 0.82 ALDH1A1 (0.50) ALDH1A1LMNAHSD17B10ALOX15MGAM
SCHEMBL25331007 0.81 HCAR2 (0.42) ALDH1A1LMNAHSD17B10GAAHCAR2
SCHEMBL2945943 0.80 GAA (0.46) ALDH1A1LMNAHSD17B10ALOX15MGAM
SCHEMBL6824967 0.80 ALDH1A1 (0.48) ALDH1A1LMNAHSD17B10ALOX15MGAM
SCHEMBL11362305 0.79 SOAT1 (0.41) ALDH1A1LMNAHSD17B10ALOX15MGAM
SCHEMBL2948744 0.79 ALDH1A1 (0.48) ALDH1A1LMNAHSD17B10ALOX15MGAM
SCHEMBL16811720 0.78 ALDH1A1 (0.46) ALDH1A1LMNAHSD17B10ALOX15MGAM
SCHEMBL16811738 0.78 ALDH1A1 (0.46) ALDH1A1LMNAHSD17B10ALOX15MGAM
SCHEMBL2941847 0.78 ALDH1A1 (0.46) ALDH1A1LMNAHSD17B10ALOX15MGAM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5258062-A Ceramic packages for semiconductor devices SHINKO ELECTRIC INDUSTRIES CO., LTD. (JP) 1993-11-02 US claimed
WO-2024070622-A1 CARBOXYL GROUP-CONTAINING ACRYLIC RUBBER COMPOSITION AND CROSSLINKED PRODUCT THEREOF 株式会社大阪ソーダ 2024-04-04 WO disclosed
EP-4223511-A1 CARBOXYL GROUP-CONTAINING ACRYLIC RUBBER COMPOSITION AND MULTILAYER BODY Osaka Soda Co., Ltd. (JP) 2023-08-09 EP disclosed
CN-116056886-A Carboxyl group-containing acrylic rubber composition and laminate 株式会社大阪曹达 2023-05-02 CN disclosed
WO-2022071217-A1 CARBOXYL GROUP-CONTAINING ACRYLIC RUBBER COMPOSITION AND MULTILAYER BODY 株式会社大阪ソーダ 2022-04-07 WO disclosed
US-20210289794-A1 COMPOSITIONS AND RELATED METHODS FOR AGRICULTURE FLAGSHIP PIONEERING INNOVATIONS V, INC. 2021-09-23 US disclosed
CN-108358877-B Furyl o-diketone derivative and preparation method thereof 沅江华龙催化科技有限公司 2020-06-02 CN disclosed
CN-104487485-B polycarbonate polyol composition and method 沙特阿美技术公司 2018-04-20 CN disclosed
EP-2970258-B1 NOVEL INHIBITOR COMPOUNDS OF PHOSPHODIESTERASE TYPE 10A ABBVIE DEUTSCHLAND (DE) 2018-04-18 EP disclosed
US-9782390-B2 Amidine substituted β-lactam compounds, their preparation and use as antibacterial agents AICURIS GMBH & CO. KG (DE) 2017-10-10 US disclosed
EP-0451207-A4 METHOD FOR REDUCING EMISSIONS FROM OR INCREASING THE UTILIZABLE ENERGY OF FUEL FOR POWERING INTERNAL COMBUSTION ENGINES 1991-11-06 EP disclosed
EP-0451207-A1 METHOD FOR REDUCING EMISSIONS FROM OR INCREASING THE UTILIZABLE ENERGY OF FUEL FOR POWERING INTERNAL COMBUSTION ENGINES. FUEL TECH INC (US) 1991-10-16 EP disclosed
EP-0447484-A1 ANTIBACTERIAL QUINOLONE COMPOUNDS THE UPJOHN COMPANY (US) 1991-09-25 EP disclosed
WO-1990007561-A1 METHOD FOR REDUCING EMISSIONS FROM OR INCREASING THE UTILIZABLE ENERGY OF FUEL FOR POWERING INTERNAL COMBUSTION ENGINES FUEL TECH, INC. (US) 1990-07-12 WO disclosed
US-4888332-A ANTIBIOTICS MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 1989-12-19 US disclosed
US-4866095-A 1,8-dihydroxy-9-anthrones for treating warts or psoriasis GROUPEMENT D'INTERET ECONOMIQUE DIT: CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIEQUES C.I.R.D. (FR) 1989-09-12 US disclosed
US-4558069-A TREATMENT OF SKIN DISORDERS GROUPEMENT D'INTERET ECONOMIQUE DIT: CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.I.R.D. (FR) 1985-12-10 US disclosed
EP-0150507-A2 Cephalosporin derivatives, processes for producing the same and compositions containing them MOCHIDA PHARMACEUTICAL CO., LTD. (JP) 1985-08-07 EP disclosed
US-4465688-A FOR TREATMENT OF SKIN DISORDERS GROUPEMENT D'INTERET ECONOMIQUE CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.I.R.D. (FR) 1984-08-14 US disclosed
US-4464301-A FOR TREATMENT OF PSORIASIS GROUPEMENT D'INTERET ECONOMIQUE CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES C.I.R.D. (FR) 1984-08-07 US disclosed