Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adenosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.77 |
| ▸ | ADORA2A known ✓ | P29274 | 1/20 | 0.77 |
| ▸ | ADORA2B known ✓ | P29275 | 1/20 | 0.77 |
| ▸ | ADORA1 known ✓ | P30542 | 1/20 | 0.77 |
| ▸ | DOT1L | Q8TEK3 | 6/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.77 |
| ▸ | DPP4 | P27487 | 1/20 | 0.77 |
| ▸ | MEN1 | O00255 | 1/20 | 0.77 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.77 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.77 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.77 |
| ▸ | GAPDH | P04406 | 1/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.77 |
| ▸ | STAT6 | P42226 | 1/20 | 0.77 |
| ▸ | PI4KA | P42356 | 1/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.77 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.77 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.77 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.77 |
| ▸ | SLC28A3 | Q9HAS3 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adenosine SCHEMBL28045831 | 0.91 | DOT1L (0.78) | DOT1LKMT2ADPP4MEN1SLC28A1 | |
| Adenosine SCHEMBL29233226 | 0.90 | EHMT2 (0.75) | DOT1LKMT2ADPP4MEN1SLC28A1 | |
| Adenosine SCHEMBL27579066 | 0.90 | NNMT (0.77) | DOT1LKMT2ADPP4MEN1SLC28A1 | |
| Adenosine SCHEMBL6408986 | 0.89 | NNMT (0.76) | DOT1LKMT2ADPP4MEN1SLC28A1 | |
| Adenosine SCHEMBL6408967 | 0.89 | NNMT (0.76) | DOT1LKMT2ADPP4MEN1SLC28A1 | |
| Adenosine SCHEMBL2985961 | 0.89 | ADORA3 (0.85) | DOT1LKMT2ADPP4MEN1SLC28A1 | |
| Adenosine SCHEMBL9295609 | 0.89 | ADORA3 (0.85) | DOT1LKMT2ADPP4MEN1SLC28A1 | |
| Adenosine SCHEMBL9426528 | 0.89 | ADORA3 (0.89) | DOT1LKMT2ADPP4MEN1SLC28A1 | |
| Adenosine SCHEMBL31364221 | 0.88 | DOT1L (0.83) | DOT1LKMT2ADPP4MEN1SLC28A1 | |
| Adenosine SCHEMBL4401875 | 0.88 | ADORA3 (0.87) | DOT1LKMT2ADPP4MEN1SLC28A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160120894-A1 | USE OF ADENOSINE ASPARTATE IN THE DIFFERENTIAL ACTIVATION OF MACROPHAGES IN INFLAMMATORY-FIBROGENIC PROCESSES AND ITS REVERSAL | UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO (MX) | 2016-05-05 | — | — | US | claimed |
| US-8507459-B2 | Use of adenosine aspartate for the preparation of pharmaceutical products for the treatment of liver cancer | UNIVERSIDAD NACIONAL AUTONNOMA DE MEXICO (MX) | 2013-08-13 | — | — | US | claimed |
| US-20110105425-A1 | USE OF ADENOSINE ASPARTATE FOR THE PREPARATION OF PHARMACEUTICAL PRODUCTS FOR THE TREATMENT OF LIVER CANCER | UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO (MX) | 2011-05-05 | — | — | US | claimed |
| EP-2186519-A1 | USE OF ADENOSINE ASPARTATE FOR THE PREPARATION OF PHARMACEUTICAL PRODUCTS FOR THE TREATMENT OF LIVER CANCER | UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO (MX) | 2010-05-19 | — | — | EP | claimed |
| US-20160120894-A1 | USE OF ADENOSINE ASPARTATE IN THE DIFFERENTIAL ACTIVATION OF MACROPHAGES IN INFLAMMATORY-FIBROGENIC PROCESSES AND ITS REVERSAL | UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO (MX) | 2016-05-05 | — | — | US | disclosed |
| US-20160120894-A1 | USE OF ADENOSINE ASPARTATE IN THE DIFFERENTIAL ACTIVATION OF MACROPHAGES IN INFLAMMATORY-FIBROGENIC PROCESSES AND ITS REVERSAL | UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO (MX) | 2016-05-05 | — | — | US | disclosed |
| US-20160120894-A1 | USE OF ADENOSINE ASPARTATE IN THE DIFFERENTIAL ACTIVATION OF MACROPHAGES IN INFLAMMATORY-FIBROGENIC PROCESSES AND ITS REVERSAL | UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO (MX) | 2016-05-05 | — | — | US | disclosed |
| WO-2014189349-A1 | USE OF ADENOSINE ASPARTATE IN THE DIFFERENTIAL ACTIVATION OF MACROPHAGES IN INFLAMMATORY-FIBROGENIC PROCESSES AND THE REVERSION THEREOF | Universidad Nacional Autónoma de México (MX) | 2014-11-27 | — | — | WO | disclosed |
| WO-2014189349-A1 | USE OF ADENOSINE ASPARTATE IN THE DIFFERENTIAL ACTIVATION OF MACROPHAGES IN INFLAMMATORY-FIBROGENIC PROCESSES AND THE REVERSION THEREOF | Universidad Nacional Autónoma de México (MX) | 2014-11-27 | — | — | WO | disclosed |
| US-8507459-B2 | Use of adenosine aspartate for the preparation of pharmaceutical products for the treatment of liver cancer | UNIVERSIDAD NACIONAL AUTONNOMA DE MEXICO (MX) | 2013-08-13 | — | — | US | disclosed |
| US-8507459-B2 | Use of adenosine aspartate for the preparation of pharmaceutical products for the treatment of liver cancer | UNIVERSIDAD NACIONAL AUTONNOMA DE MEXICO (MX) | 2013-08-13 | — | — | US | disclosed |
| US-8507459-B2 | Use of adenosine aspartate for the preparation of pharmaceutical products for the treatment of liver cancer | UNIVERSIDAD NACIONAL AUTONNOMA DE MEXICO (MX) | 2013-08-13 | — | — | US | disclosed |
| US-20110105425-A1 | USE OF ADENOSINE ASPARTATE FOR THE PREPARATION OF PHARMACEUTICAL PRODUCTS FOR THE TREATMENT OF LIVER CANCER | UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO (MX) | 2011-05-05 | — | — | US | disclosed |
| US-20110105425-A1 | USE OF ADENOSINE ASPARTATE FOR THE PREPARATION OF PHARMACEUTICAL PRODUCTS FOR THE TREATMENT OF LIVER CANCER | UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO (MX) | 2011-05-05 | — | — | US | disclosed |
| EP-2186519-A4 | USE OF ADENOSINE ASPARTATE FOR THE PREPARATION OF PHARMACEUTICAL PRODUCTS FOR THE TREATMENT OF LIVER CANCER | UNIV MEXICO NACIONAL AUTONOMA (MX) | 2010-09-01 | — | — | EP | disclosed |
| EP-2186519-A1 | USE OF ADENOSINE ASPARTATE FOR THE PREPARATION OF PHARMACEUTICAL PRODUCTS FOR THE TREATMENT OF LIVER CANCER | UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO (MX) | 2010-05-19 | — | — | EP | disclosed |
| EP-2186519-A1 | USE OF ADENOSINE ASPARTATE FOR THE PREPARATION OF PHARMACEUTICAL PRODUCTS FOR THE TREATMENT OF LIVER CANCER | UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO (MX) | 2010-05-19 | — | — | EP | disclosed |
| EP-2186519-A1 | USE OF ADENOSINE ASPARTATE FOR THE PREPARATION OF PHARMACEUTICAL PRODUCTS FOR THE TREATMENT OF LIVER CANCER | UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO (MX) | 2010-05-19 | — | — | EP | disclosed |
| WO-2009031876-A1 | USE OF ADENOSINE ASPARTATE FOR THE PREPARATION OF PHARMACEUTICAL PRODUCTS FOR THE TREATMENT OF LIVER CANCER | UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO (MX) | 2009-03-12 | — | — | WO | disclosed |
| WO-2009031876-A1 | USE OF ADENOSINE ASPARTATE FOR THE PREPARATION OF PHARMACEUTICAL PRODUCTS FOR THE TREATMENT OF LIVER CANCER | UNIVERSIDAD NACIONAL AUTONOMA DE MEXICO (MX) | 2009-03-12 | — | — | WO | disclosed |