Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.41 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3783104 | 0.83 | POLB (0.41) | MAPTALDH1A1LMNAGAAPOLB | |
| SCHEMBL3780160 | 0.81 | MAPT (0.38) | MAPTALDH1A1HRH3LMNAGAA | |
| SCHEMBL3786743 | 0.78 | POLB (0.38) | MAPTALDH1A1LMNAGAAPOLB | |
| SCHEMBL3784012 | 0.78 | POLB (0.39) | MAPTALDH1A1LMNAGAAPOLB | |
| SCHEMBL3787757 | 0.78 | POLB (0.39) | MAPTALDH1A1LMNAGAAPOLB | |
| SCHEMBL20019687 | 0.76 | ADRB1 (0.35) | MAPTALDH1A1HRH3LMNAADRB1 | |
| SCHEMBL20019617 | 0.75 | ALDH1A1 (0.37) | MAPTALDH1A1LMNAGAAPOLB | |
| SCHEMBL22426724 | 0.74 | MAPT (0.43) | MAPTALDH1A1LMNAGAAPOLB | |
| SCHEMBL19313630 | 0.73 | ALDH1A1 (0.41) | MAPTALDH1A1LMNANPC1GAA | |
| SCHEMBL22340249 | 0.73 | HPGD (0.37) | ALDH1A1LMNANPC1FKBP1APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018112037-A1 | INHIBITORS OF BROMODOMAIN-CONTAINING PROTEIN 4 (BRD4) | ZHOU JIA (US) | 2018-06-21 | — | — | WO | disclosed |
| EP-3077386-B1 | BENZHYDRYL DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DISEASES | CHIESI FARM SPA (IT) | 2017-09-06 | — | — | EP | disclosed |
| WO-2017034245-A1 | JANUS KINASE 1 SELECTIVE INHIBITOR AND PHARMACEUTICAL USE THEREOF | 양지화학 주식회사 | 2017-03-02 | — | — | WO | disclosed |