SCHEMBL1858652

SCHEMBL1858652

Oc1ccc(Br)cc1Cc1ccccc1

nearest known ligand 0.62

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HPGD P15428 2/20 0.62
MEN1 O00255 1/20 0.62
CYP3A4 P08684 1/20 0.62
ALOX15 P16050 1/20 0.62
KMT2A Q03164 1/20 0.62
HIF1A Q16665 1/20 0.62
HSD17B10 Q99714 1/20 0.62
BCL2 P10415 1/20 0.59
BCL2L1 Q07817 1/20 0.59
ALDH1A1 P00352 1/20 0.54
HTT P42858 1/20 0.54
ALOX5 P09917 1/20 0.52
IDH1 O75874 1/20 0.50
SLC7A5 Q01650 1/20 0.50
TSHR P16473 2/20 0.49
KEAP1 Q14145 1/20 0.46
GFER P55789 1/20 0.45
PTGES O14684 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL68224 0.83 ALOX15 (0.54) HPGDMEN1CYP3A4ALOX15KMT2A
Clorophene SCHEMBL28270037 0.83 MEN1 (0.81) HPGDMEN1CYP3A4ALOX15KMT2A
SCHEMBL8406689 0.83 HTT (0.53) HPGDMEN1CYP3A4ALOX15KMT2A
SCHEMBL4813970 0.81 ALDH1A1 (0.61) HPGDMEN1CYP3A4ALOX15KMT2A
SCHEMBL3152055 0.81 MAPT (0.47) HPGDMEN1CYP3A4ALOX15KMT2A
SCHEMBL28631519 0.81 MAOB (0.45) HPGDMEN1CYP3A4ALOX15KMT2A
SCHEMBL390179 0.80 ALOX5 (0.71) HPGDMEN1CYP3A4ALOX15KMT2A
SCHEMBL10886054 0.80 IDH1 (0.70) HPGDMEN1CYP3A4ALOX15KMT2A
SCHEMBL9173452 0.80 IDH1 (0.70) HPGDMEN1CYP3A4ALOX15KMT2A
SCHEMBL10558399 0.80 MEN1 (0.67) HPGDMEN1CYP3A4ALOX15KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-59216896-A None JP disclosed
US-20240239761-A1 BICYCLIC PHENOL COMPOUNDS AND USE THEREOF MEDSHINE DISCOVERY INC. (CN) 2024-07-18 US disclosed
EP-4310077-A1 BICYCLIC PHENOL COMPOUNDS AND USE THEREOF Medshine Discovery Inc. (CN) 2024-01-24 EP disclosed
CN-116693580-A Anthracene skeleton phenol oxygen single metallocene bimetallic catalyst, preparation method and application 万华化学集团股份有限公司 2023-09-05 CN disclosed
WO-2021262684-A1 METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION PMV PHARMACEUTICALS, INC. (US) 2021-12-30 WO disclosed
US-20110105608-A1 MODULATORS OF NUCLEAR RECEPTOR CO-REGULATORY PROTEIN BINDING NORTHEASTERN UNIVERSITY (US) 2011-05-05 US disclosed
US-20110105608-A1 MODULATORS OF NUCLEAR RECEPTOR CO-REGULATORY PROTEIN BINDING NORTHEASTERN UNIVERSITY (US) 2011-05-05 US disclosed
US-20110105608-A1 MODULATORS OF NUCLEAR RECEPTOR CO-REGULATORY PROTEIN BINDING NORTHEASTERN UNIVERSITY (US) 2011-05-05 US disclosed
WO-2009117739-A1 MODULATORS OF NUCLEAR RECEPTOR CO-REGULATORY PROTEIN BINDING NORTHEASTERN UNIVERSITY (US) 2009-09-24 WO disclosed
WO-2009117739-A1 MODULATORS OF NUCLEAR RECEPTOR CO-REGULATORY PROTEIN BINDING NORTHEASTERN UNIVERSITY (US) 2009-09-24 WO disclosed
EP-1408986-A4 PROTEOMIMETIC COMPOUNDS AND METHODS UNIV YALE (US) 2006-01-11 EP disclosed
US-20050215563-A1 Proteomimetic compounds and methods YALE UNIVERSITY 2005-09-29 US disclosed
US-6858600-B2 Proteomimetic compounds and methods YALE UNIVERSITY (US) 2005-02-22 US disclosed
EP-1408986-A2 PROTEOMIMETIC COMPOUNDS AND METHODS YALE UNIVERSITY (US) 2004-04-21 EP disclosed
EP-1081132-B1 HYDROXAMIC ACID DERIVATIVES AND MEDICINAL UTILIZATION THEREOF MITSUBISHI PHARMA CORP (JP) 2004-03-10 EP disclosed
US-6610729-B1 Inhibotors of TNF, antiinflammatory MITSUBISHI PHARMA CORPORATION (JP) 2003-08-26 US disclosed
US-20030008882-A1 Proteomimetic compounds and methods NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2003-01-09 US disclosed
WO-2002089738-A2 PROTEOMIMETIC COMPOUNDS AND METHODS YALE UNIVERSITY (US) 2002-11-14 WO disclosed
EP-1081132-A1 HYDROXAMIC ACID DERIVATIVES AND MEDICINAL UTILIZATION THEREOF Welfide Corporation (JP) 2001-03-07 EP disclosed
JP-S59216896-A ORGANIC PHOSPHORIC ESTER AND INSECTICIDE AND ACARICIDE SANKYO CO LTD 1984-12-06 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030008882-A1 Proteomimetic compounds and methods PACSIN2, HSP90B1, PHLPP2 HPGD 3501/4885MEN1 3279/4885CYP3A4 4622/4885
US-20110105608-A1 MODULATORS OF NUCLEAR RECEPTOR CO-REGULATORY PROTEIN BINDING ESRRB, ESRRA, ESRRG HPGD 1753/4885MEN1 4713/4885CYP3A4 4199/4885
US-20240239761-A1 BICYCLIC PHENOL COMPOUNDS AND USE THEREOF CYP3A43, CYP11B2, UGT2B7 HPGD 538/4885MEN1 4141/4885CYP3A4 35/4885
US-20050215563-A1 Proteomimetic compounds and methods PACSIN2, HSP90B1, PHLPP2 HPGD 3501/4885MEN1 3279/4885CYP3A4 4622/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.