Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.76 |
| ▸ | TSHR | P16473 | 2/20 | 0.76 |
| ▸ | MAPT | P10636 | 2/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.76 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.76 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.76 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.76 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.76 |
| ▸ | LMNA | P02545 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | PKM | P14618 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | BLM | P54132 | 1/20 | 0.67 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.62 |
| ▸ | CTSC | P53634 | 1/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | TACR3 | P29371 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL761706 | 0.89 | MEN1 (0.75) | MEN1KMT2AALDH1A1TSHRMAPT | |
| Nematophin SCHEMBL29466301 | 0.88 | MMP9 (0.65) | MEN1KMT2AALDH1A1TSHRMAPT | |
| SCHEMBL17037428 | 0.86 | MEN1 (0.70) | MEN1KMT2AALDH1A1TSHRMAPT | |
| SCHEMBL10554058 | 0.85 | MEN1 (0.64) | MEN1KMT2AALDH1A1TSHRMAPT | |
| SCHEMBL7677879 | 0.84 | MEN1 (0.67) | MEN1KMT2AALDH1A1TSHRMAPT | |
| SCHEMBL9118606 | 0.84 | MEN1 (0.71) | MEN1KMT2AALDH1A1TSHRMAPT | |
| SCHEMBL6892616 | 0.81 | KMT2A (0.83) | MEN1KMT2AALDH1A1TSHRMAPT | |
| SCHEMBL6365945 | 0.81 | MEN1 (0.65) | MEN1KMT2AALDH1A1TSHRMAPT | |
| SCHEMBL15145390 | 0.81 | CTSC (0.71) | MEN1KMT2AALDH1A1TSHRMAPT | |
| SCHEMBL31114206 | 0.81 | MTNR1A (0.76) | MEN1KMT2ATSHRMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9586931-B2 | Triazolyl derivatives as Syk inhibitors | MERCK SHARP & DOHME CORP. (US) | 2017-03-07 | — | — | US | disclosed |