Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18597716 | 0.84 | FFAR1 (0.48) | EPHX1 | |
| SCHEMBL1240 | 0.84 | CYP1A2 (0.40) | LMNANPSR1RAB9ATSHRMAPT | |
| SCHEMBL18597914 | 0.81 | THRB (0.39) | BRD4NPSR1KDM4EMAPTEPHX1 | |
| SCHEMBL1306 | 0.80 | LMNA (0.37) | LMNABRD4RAB9ATSHRUSP2 | |
| SCHEMBL1852 | 0.80 | RXFP1 (0.40) | LMNANPSR1MAPTEPHX1ALDH1A1 | |
| SCHEMBL1626 | 0.80 | LMNA (0.37) | LMNABRD4RAB9ATSHRUSP2 | |
| SCHEMBL6841 | 0.78 | CYP1A2 (0.38) | LMNANPSR1RAB9ATSHRMAPT | |
| SCHEMBL1627 | 0.76 | EPHX1 (0.41) | LMNABRD4EPHX1GSK3BHDAC3 | |
| SCHEMBL1307 | 0.76 | EPHX1 (0.41) | LMNABRD4EPHX1GSK3BHDAC3 | |
| SCHEMBL1853 | 0.75 | EPHX1 (0.41) | LMNABRD4RAB9AEPHX1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-B1 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS INC (US) | 2017-03-08 | — | — | EP | disclosed |