Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 5/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | KCNA5 | P22460 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | FDPS | P14324 | 1/20 | 0.34 |
| ▸ | PTPRA | P18433 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | PTGFR | P43088 | 1/20 | 0.33 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18598758 | 0.78 | KCNH2 (0.39) | TSHRCYP1A2CYP3A4KCNA5ALDH1A1 | |
| SCHEMBL23986930 | 0.78 | NOS3 (0.41) | TSHRCYP1A2KCNA5ALDH1A1KCNH2 | |
| SCHEMBL20666526 | 0.78 | ALDH1A1 (0.40) | TSHRCYP1A2CYP3A4KCNA5ALDH1A1 | |
| SCHEMBL22222009 | 0.70 | ALDH1A1 (0.35) | TSHRCYP1A2CYP3A4ALDH1A1KCNH2 | |
| SCHEMBL22725661 | 0.70 | TSHR (0.38) | TSHRCYP1A2CYP3A4KCNA5ALDH1A1 | |
| SCHEMBL13638230 | 0.69 | KCNA5 (0.52) | TSHRCYP1A2CYP3A4KCNA5ALDH1A1 | |
| SCHEMBL13862942 | 0.69 | KCNA5 (0.52) | TSHRCYP1A2CYP3A4KCNA5ALDH1A1 | |
| SCHEMBL10247782 | 0.69 | KCNA5 (0.52) | TSHRCYP1A2CYP3A4KCNA5ALDH1A1 | |
| SCHEMBL817770 | 0.69 | KCNA5 (0.52) | TSHRCYP1A2CYP3A4KCNA5ALDH1A1 | |
| SCHEMBL3249970 | 0.69 | MAOA (0.50) | TSHRCYP1A2KCNA5ALDH1A1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2920183-B1 | THIENO[3,2-C]PYRIDIN-4(5H)-ONES AS BET INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2017-03-08 | — | — | EP | disclosed |