Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 4/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
| ▸ | PTGFR | P43088 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.37 |
| ▸ | DRD1 | P21728 | 2/20 | 0.37 |
| ▸ | HRH1 | P35367 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | SCN1A | P35498 | 2/20 | 0.37 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.37 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15716829 | 0.79 | GABRA1 (0.38) | KCNA5KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL20918638 | 0.78 | GABRP (0.41) | LMNATSHRGAASMN1; SMN2 | |
| SCHEMBL15728143 | 0.77 | CHRM2 (0.40) | KCNA5KCNH2PTGFRSLC6A2SLC6A4 | |
| SCHEMBL18598758 | 0.77 | KCNH2 (0.39) | KCNA5KCNH2PTGFRSLC6A2SLC6A4 | |
| SCHEMBL19782624 | 0.75 | LMNA (0.42) | LMNAMEN1GAAKMT2ASMN1; SMN2 | |
| SCHEMBL8906066 | 0.75 | TSHR (0.42) | KCNA5KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL19782626 | 0.75 | LMNA (0.42) | LMNAMEN1GAAKMT2ASMN1; SMN2 | |
| SCHEMBL18598770 | 0.75 | CHRNB2 (0.38) | KCNH2PTGFRSLC6A2SLC6A4SLC6A3 | |
| SCHEMBL13512389 | 0.73 | TSHR (0.46) | KCNA5KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL2093049 | 0.73 | TSHR (0.46) | KCNA5KCNH2SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2920183-B1 | THIENO[3,2-C]PYRIDIN-4(5H)-ONES AS BET INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2017-03-08 | — | — | EP | disclosed |