Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.32 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.32 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9918207 | 1.00 | TP53 (0.38) | TP53ALDH1A1HTTSMN1; SMN2MAPT | |
| SCHEMBL9918824 | 0.91 | HPGD (0.39) | TP53ALDH1A1HTTSMN1; SMN2MAPT | |
| SCHEMBL9918202 | 0.86 | TRPV4 (0.36) | — | |
| SCHEMBL9918206 | 0.85 | LMNA (0.38) | ALDH1A1HTTSMN1; SMN2MAPTTSHR | |
| SCHEMBL9921720 | 0.85 | TP53 (0.40) | TP53ALDH1A1HTTSMN1; SMN2MAPT | |
| SCHEMBL12251263 | 0.85 | ALDH1A1 (0.33) | ALDH1A1HTTSMN1; SMN2MAPTHPGD | |
| SCHEMBL13678297 | 0.84 | — | — | |
| SCHEMBL171764 | 0.81 | SGMS2 (0.34) | ALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL16691093 | 0.80 | TP53 (0.38) | TP53ALDH1A1HTTSMN1; SMN2MAPT | |
| SCHEMBL19062265 | 0.79 | TP53 (0.37) | TP53ALDH1A1HTTSMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2348023-B9 | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as Janus kinase inhibitors | INCYTE HOLDINGS CORP (US) | 2017-03-08 | — | — | EP | disclosed |