Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 1/20 | 0.47 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3108687 | 0.85 | CHRNB4 (0.55) | CYP11B2RIPK2CHRNB2CHRNA4CHRNB4 | |
| SCHEMBL3103772 | 0.82 | CHRNB2 (0.52) | CYP11B2RIPK2CHRNB2CHRNA4KDM4E | |
| SCHEMBL15716470 | 0.81 | CYP11B2 (0.45) | CYP11B2RIPK2CHRNB2CHRNA4CHRNB4 | |
| Lithium SCHEMBL29705636 | 0.74 | CYP11B2 (0.45) | CYP11B2RIPK2CHRNB2CHRNA4KDM4E | |
| SCHEMBL12525730 | 0.72 | SLC2A1 (0.46) | XDHSLC2A1KDM4C | |
| SCHEMBL13096931 | 0.72 | CYP2D6 (0.39) | CYP11B2CHRNB4CHRNA3CYP2D6XDH | |
| SCHEMBL19405964 | 0.72 | CHRNB4 (0.61) | CHRNB2CHRNA4CHRNB4CHRNA3KDM4E | |
| SCHEMBL13097262 | 0.71 | CHRNB4 (0.46) | CYP11B2CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL4909692 | 0.71 | PIK3CA (0.44) | CYP2D6XDH | |
| SCHEMBL29136349 | 0.70 | DHFR (0.40) | CYP11B2CYP2D6XDHSLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2920183-B1 | THIENO[3,2-C]PYRIDIN-4(5H)-ONES AS BET INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2017-03-08 | — | — | EP | disclosed |