Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | GRM5 | P41594 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.35 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.35 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.35 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.35 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.35 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.35 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28940910 | 0.82 | ALDH1A1 (0.52) | ALDH1A1KDM4EHSD17B10ALOX15HPGD | |
| SCHEMBL185620 | 0.78 | LMNA (0.35) | ALDH1A1KDM4EHSD17B10ALOX15HPGD | |
| SCHEMBL185449 | 0.76 | ALDH1A1 (0.33) | ALDH1A1KDM4EHSD17B10ALOX15HPGD | |
| SCHEMBL7020112 | 0.76 | ALDH1A1 (0.33) | ALDH1A1KDM4EHSD17B10ALOX15HPGD | |
| SCHEMBL185429 | 0.75 | ALDH1A1 (0.40) | ALDH1A1KDM4EHSD17B10ALOX15HPGD | |
| SCHEMBL185994 | 0.74 | ALDH1A1 (1.00) | ALDH1A1KDM4EHSD17B10ALOX15HPGD | |
| SCHEMBL186176 | 0.74 | HDAC1 (0.42) | ALDH1A1KDM4EHPGDMEN1KMT2A | |
| SCHEMBL198068 | 0.73 | CCNE1 (0.35) | ALDH1A1KDM4EHSD17B10ALOX15HPGD | |
| SCHEMBL186008 | 0.73 | GRM5 (0.39) | ALDH1A1KDM4EHSD17B10ALOX15HPGD | |
| SCHEMBL16712250 | 0.73 | SMN1; SMN2 (0.34) | ALDH1A1KDM4EHSD17B10ALOX15HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |