Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.42 |
| ▸ | GABRP | O00591 | 3/20 | 0.38 |
| ▸ | GABRD | O14764 | 3/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.38 |
| ▸ | GABRE | P78334 | 3/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.38 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.38 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.38 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28049475 | 0.84 | ALDH1A1 (0.45) | HDAC1HDAC6ALDH1A1KDM4EHSP90AA1 | |
| SCHEMBL29225190 | 0.82 | KMT2A (0.45) | HDAC1HDAC6GABRPGABRDGABRA1 | |
| SCHEMBL185449 | 0.79 | ALDH1A1 (0.33) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7020112 | 0.79 | ALDH1A1 (0.33) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL9235248 | 0.78 | GABRP (0.53) | HDAC1HDAC6GABRPGABRDGABRA1 | |
| SCHEMBL185620 | 0.77 | LMNA (0.35) | ALDH1A1KDM4EMEN1LMNAKMT2A | |
| SCHEMBL10588692 | 0.77 | HDAC1 (0.42) | HDAC1HDAC6ALDH1A1KDM4EHSP90AA1 | |
| SCHEMBL27503300 | 0.77 | THRB (0.40) | HDAC1HDAC6GABRPGABRDGABRA1 | |
| SCHEMBL27548231 | 0.77 | PARP10 (0.54) | ALDH1A1MEN1LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL185429 | 0.74 | ALDH1A1 (0.40) | ALDH1A1KDM4ELMNAKMT2ANNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2401256-B1 | Compounds as bradykinin B1 antagonists | BOEHRINGER INGELHEIM INT (DE) | 2013-04-17 | — | — | EP | disclosed |
| EP-2401256-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | Boehringer Ingelheim International GmbH (DE) | 2012-01-04 | — | — | EP | disclosed |
| WO-2010097372-A1 | COMPOUNDS AS BRADYKININ B1 ANTAGONISTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-09-02 | — | — | WO | disclosed |
| EP-0325131-A2 | Pyrimidine derivatives as performance stimulating agents | BAYER AG (DE) | 1989-07-26 | — | — | EP | disclosed |