Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ4 | P56696 | 4/20 | 0.48 |
| ▸ | PYCR1 | P32322 | 2/20 | 0.48 |
| ▸ | KCNQ5 | Q9NR82 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.47 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.47 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | TYMS | P04818 | 2/20 | 0.36 |
| ▸ | DHFR | P00374 | 2/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18600203 | 0.88 | PYCR1 (0.47) | KCNQ4PYCR1KCNQ5CYP1A2CYP2C8 | |
| SCHEMBL18600545 | 0.83 | CNR2 (0.47) | CYP3A4TSHRCNR1CNR2 | |
| SCHEMBL15996915 | 0.80 | PYCR1 (0.53) | KCNQ4PYCR1KCNQ5CYP1A2CYP2C8 | |
| SCHEMBL15997126 | 0.77 | KCNQ4 (0.53) | KCNQ4PYCR1KCNQ5CYP1A2CYP2C8 | |
| SCHEMBL18600201 | 0.77 | PYCR1 (0.58) | KCNQ4PYCR1KCNQ5CYP1A2CYP2C8 | |
| SCHEMBL18600155 | 0.76 | PYCR1 (0.53) | KCNQ4PYCR1KCNQ5CYP1A2CYP2C8 | |
| SCHEMBL30494445 | 0.76 | KCNQ4 (0.60) | KCNQ4PYCR1KCNQ5CYP1A2CYP2C8 | |
| SCHEMBL15996909 | 0.74 | KCNQ2 (0.58) | KCNQ4PYCR1KCNQ5CYP1A2CYP2C8 | |
| SCHEMBL15996890 | 0.73 | CYP1A2 (0.72) | KCNQ4PYCR1KCNQ5CYP1A2CYP2C8 | |
| SCHEMBL93163 | 0.73 | CYP3A4 (0.56) | CYP1A2CYP3A4TSHRCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10316008-B2 | KCNQ potassium channel agonist, and preparation method therefor and use thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2019-06-11 | — | — | US | disclosed |
| US-20180134677-A1 | NOVEL KCNQ POTASSIUM CHANNEL AGONIST, AND PREPARATION METHOD THEREFOR AND USE THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2018-05-17 | — | — | US | disclosed |
| US-20180134677-A1 | NOVEL KCNQ POTASSIUM CHANNEL AGONIST, AND PREPARATION METHOD THEREFOR AND USE THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2018-05-17 | — | — | US | disclosed |
| US-20170081301-A1 | NOVEL KCNQ POTASSIUM CHANNEL AGONISTS, METHOD OF PREPARATION AND METHOD OF USE THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2017-03-23 | — | — | US | disclosed |
| US-20170081301-A1 | NOVEL KCNQ POTASSIUM CHANNEL AGONISTS, METHOD OF PREPARATION AND METHOD OF USE THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2017-03-23 | — | — | US | disclosed |
| EP-3138833-A1 | NOVEL KCNQ POTASSIUM CHANNEL AGONIST, AND PREPARATION METHOD THEREFOR AND USE THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2017-03-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180134677-A1 | NOVEL KCNQ POTASSIUM CHANNEL AGONIST, AND PREPARATION METHOD THEREFOR AND USE THEREOF | KCNQ5, KCNQ4, KCNQ1 | KCNQ4 2/4885PYCR1 2084/4885KCNQ5 1/4885 |
| US-10316008-B2 | KCNQ potassium channel agonist, and preparation method therefor and use thereof | KCNQ5, KCNQ4, KCNQ3 | KCNQ4 2/4885PYCR1 2601/4885KCNQ5 1/4885 |
| US-20170081301-A1 | NOVEL KCNQ POTASSIUM CHANNEL AGONISTS, METHOD OF PREPARATION AND METHOD OF USE THEREOF | KCNQ5, KCNQ4, KCNQ3 | KCNQ4 2/4885PYCR1 2452/4885KCNQ5 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.