Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ4 | P56696 | 4/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.60 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.60 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.57 |
| ▸ | KCNQ5 | Q9NR82 | 3/20 | 0.56 |
| ▸ | PYCR1 | P32322 | 2/20 | 0.46 |
| ▸ | CETP | P11597 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | NAMPT | P43490 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15997126 | 0.86 | KCNQ4 (0.53) | KCNQ4CYP1A2CYP2C8CYP2B6KCNQ2 | |
| SCHEMBL15996890 | 0.86 | CYP1A2 (0.72) | KCNQ4CYP1A2CYP2C8CYP2B6KCNQ2 | |
| SCHEMBL15996884 | 0.86 | KCNQ4 (0.78) | KCNQ4CYP1A2CYP2C8CYP2B6KCNQ2 | |
| SCHEMBL20159076 | 0.85 | KCNQ4 (0.56) | KCNQ4CYP1A2CYP2C8CYP2B6KCNQ2 | |
| SCHEMBL18600341 | 0.84 | KCNQ4 (0.55) | KCNQ4CYP1A2CYP2C8CYP2B6KCNQ2 | |
| SCHEMBL18575369 | 0.83 | ALDH1A1 (0.61) | KCNQ4CYP1A2CYP2C8CYP2B6KCNQ2 | |
| SCHEMBL18600345 | 0.83 | CYP1A2 (0.59) | KCNQ4CYP1A2CYP2C8CYP2B6KCNQ2 | |
| SCHEMBL15996899 | 0.83 | KCNQ4 (0.59) | KCNQ4CYP1A2CYP2C8CYP2B6KCNQ2 | |
| SCHEMBL18600155 | 0.82 | PYCR1 (0.53) | KCNQ4CYP1A2CYP2C8CYP2B6KCNQ2 | |
| SCHEMBL23969473 | 0.82 | KCNQ4 (0.56) | KCNQ4CYP1A2CYP2C8CYP2B6KCNQ2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023134673-A1 | HIGH-SELECTIVITY KCNQ4 POTASSIUM CHANNEL AGONIST, PREPARATION METHOD THEREFOR AND USE THEREOF | 中国科学院上海药物研究所 | 2023-07-20 | — | — | WO | disclosed |