Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14954840 | 0.84 | SMN1; SMN2 (0.40) | MAPTCYP1A2CYP2D6SMN1; SMN2RAB9A | |
| SCHEMBL4554726 | 0.84 | SMN1; SMN2 (0.38) | MAPTCYP1A2CYP2D6SMN1; SMN2RAB9A | |
| SCHEMBL4566067 | 0.83 | SMN1; SMN2 (0.40) | MAPTCYP1A2CYP2D6SMN1; SMN2RAB9A | |
| SCHEMBL4564507 | 0.82 | SMN1; SMN2 (0.39) | MAPTCYP1A2CYP2D6SMN1; SMN2RAB9A | |
| SCHEMBL4555187 | 0.82 | HTT (0.43) | MAPTSMN1; SMN2RAB9AGAAKDM4E | |
| SCHEMBL1864535 | 0.81 | SMN1; SMN2 (0.38) | MAPTSMN1; SMN2RAB9AGAAALOX15 | |
| SCHEMBL3778364 | 0.81 | SMN1; SMN2 (0.38) | MAPTCYP1A2CYP2D6SMN1; SMN2RAB9A | |
| SCHEMBL10276093 | 0.80 | RAB9A (0.41) | MAPTSMN1; SMN2RAB9ANPC1KDM4E | |
| SCHEMBL4565478 | 0.80 | KDM4E (0.38) | MAPTCYP1A2SMN1; SMN2RAB9AALOX15 | |
| SCHEMBL4385559 | 0.80 | CSNK2A2 (0.49) | MAPTSMN1; SMN2KDM4ETSHRPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8450315-B2 | Phosphoinositide 3-kinase inhibitor compounds and methods of use | GENENTECH, INC. (US) | 2013-05-28 | — | — | US | disclosed |
| US-20110105464-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. | 2011-05-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105464-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND METHODS OF USE | PI4KB, PIK3CB, PIK3C2B | NCF1 641/4885MAPT 4415/4885CYP1A2 4386/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.