Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.49 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.44 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.44 |
| ▸ | KMO | O15229 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAT2A | P31153 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4555187 | 0.89 | HTT (0.43) | CSNK2A2CSNK2BCSNK2A1PIK3CAPIK3R1 | |
| SCHEMBL1860764 | 0.80 | NCF1 (0.45) | PIK3CAPIK3R1POLBPIK3CBSMN1; SMN2 | |
| SCHEMBL4554179 | 0.80 | KMO (0.47) | PIK3CAPIK3R1KMOTSHREGLN1 | |
| SCHEMBL14954840 | 0.79 | SMN1; SMN2 (0.40) | PIK3CAPIK3R1POLBSMN1; SMN2MAT2A | |
| SCHEMBL1864535 | 0.79 | SMN1; SMN2 (0.38) | PIK3CAPIK3R1POLBSMN1; SMN2MAT2A | |
| SCHEMBL4565478 | 0.78 | KDM4E (0.38) | PIK3CAPIK3R1PIK3CBSMN1; SMN2MAT2A | |
| SCHEMBL1858728 | 0.77 | NPC1 (0.51) | PIK3CAPIK3R1POLBPIK3CDPIK3CB | |
| SCHEMBL4564369 | 0.77 | SMN1; SMN2 (0.39) | PIK3CAPIK3R1PIK3CDPIK3CBSMN1; SMN2 | |
| SCHEMBL1860558 | 0.76 | SHMT2 (0.41) | PIK3CAPIK3R1POLBSMN1; SMN2KDM4E | |
| SCHEMBL3778364 | 0.76 | SMN1; SMN2 (0.38) | PIK3CAPIK3R1POLBSMN1; SMN2MAT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046799-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Genentech, Inc. (US) | 2009-04-15 | — | — | EP | disclosed |
| WO-2007127183-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GENENTECH, INC. (US) | 2007-11-08 | — | — | WO | disclosed |