Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.38 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MAT2A | P31153 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1860764 | 0.80 | NCF1 (0.45) | KDM4EMAPTPIK3CAPIK3R1SMN1; SMN2 | |
| SCHEMBL14954840 | 0.79 | SMN1; SMN2 (0.40) | KDM4EMAPTPIK3CAPIK3R1SMN1; SMN2 | |
| SCHEMBL1864535 | 0.79 | SMN1; SMN2 (0.38) | KDM4EMAPTPIK3CAPIK3R1SMN1; SMN2 | |
| SCHEMBL4385559 | 0.78 | CSNK2A2 (0.49) | KDM4EMAPTPIK3CAPIK3R1SMN1; SMN2 | |
| SCHEMBL4555187 | 0.77 | HTT (0.43) | KDM4EMAPTPIK3CAPIK3R1SMN1; SMN2 | |
| SCHEMBL4554726 | 0.76 | SMN1; SMN2 (0.38) | KDM4EMAPTPIK3CAPIK3R1SMN1; SMN2 | |
| SCHEMBL3778364 | 0.76 | SMN1; SMN2 (0.38) | KDM4EMAPTPIK3CAPIK3R1SMN1; SMN2 | |
| SCHEMBL4566067 | 0.75 | SMN1; SMN2 (0.40) | KDM4EMAPTPIK3CAPIK3R1SMN1; SMN2 | |
| SCHEMBL10276093 | 0.75 | RAB9A (0.41) | KDM4EMAPTPIK3CAPIK3R1SMN1; SMN2 | |
| SCHEMBL4564369 | 0.74 | SMN1; SMN2 (0.39) | KDM4EMAPTPIK3CAPIK3R1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046799-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Genentech, Inc. (US) | 2009-04-15 | — | — | EP | disclosed |
| WO-2007127183-A1 | PHOSPHOINOSITIDE 3-KINASE INHIBITOR COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GENENTECH, INC. (US) | 2007-11-08 | — | — | WO | disclosed |